Published: 2021-05-05

Defining current practice patterns of vestibular schwannoma management in Italy: results of a nationwide survey

Unit of Otolaryngology, Department of BMS, Neuroscience and Sensory Organs, University of Bari, Italy
Unit of Otolaryngology, Department of BMS, Neuroscience and Sensory Organs, University of Bari, Italy
Unit of Otolaryngology, Department of BMS, Neuroscience and Sensory Organs, University of Bari, Italy
Unit of Neurosurgery, Department of BMS, Neuroscience and Sensory Organs, University of Bari, Italy
Academic Neurosurgery, Department of Neuroscience - DNS, Padua University, Padua, Italy
ENT and Skull-Base Surgery Department, Department of Neurosciences, Ospedale Papa Giovanni XXIII, Bergamo, Italy
Otolaryngology Section, Department of Neuroscience - DNS, Padua University, Padua, Italy; Section of Human Anatomy, Department of Neuroscience - DNS, Padua University, Padua, Italy; *D. Cazzador and E. Zanoletti contributed equally to this work
Otolaryngology Section, Department of Neuroscience - DNS, Padua University, Padua, Italy; *D. Cazzador and E. Zanoletti contributed equally to this work
vestibular schwannoma acoustic neuroma microsurgery stereotactic radiotherapy skull base surgery


Objective. Despite the increasing incidence rate of vestibular schwannomas (VS), controversies in their management are still present.
Methods. A 35-item multiple-choice survey investigating the current practice patterns of VS care was sent to the members of the Italian Society of Otolaryngology, Head and Neck Surgery (SIO) and of the Italian Society of Neurosurgery (SINCH).
Results. Among 66 respondents, 37 (56.0%) claimed to be actively involved in VS management. Most interviewees (35.1%) declared > 20 years of experience and 59.5% claimed to work in an academic practice. The number of cases evaluated in each centre per year varied widely, with 54.0% evaluating > 25 cases/year and only 13.6% > 100 cases/year. Multidisciplinary care for VS evaluation was confirmed by 50.0% of respondents, and multidisciplinary surgical care by 62.2%. Observation and surgery were the most common management options proposed. Further details regarding VS care are presented.
Conclusions. The present study provides the first overview on the current practice patterns of VS care in Italy. Although integrated in most centres, a multidisciplinary model of care needs to be encouraged. Wide heterogeneity in experience and practices is mostly influenced by the surgeon’s different specialties and by the lack of shared guidelines.


Vestibular schwannoma (VS) is a benign tumour arising from Schwann cells of the VIII cranial nerve and account for 5% to 9% of all brain neoplasms 1. The first evidence in the literature dates to 1777 2. About 90% of these tumours are unilateral and sporadic. They can also occur bilaterally, generally when associated with genetic conditions such as neurofibromatosis type 2 3. By exerting a compression on the VIII cranial nerve, VS leads to progressive unilateral sensorineural hearing loss (SNHL) and tinnitus in more than 90% of patients, while vestibular symptoms are present in ≤ 20%. Sudden SNHL may also be the first clinical presentation in up to 22% of cases 4.

Over the past 40 years, the incidence rate of VS has steadily increased from approximately 3 cases/million/year to 34 cases/million/year 5. This steep rise was probably due to VS early diagnosis with high-resolution contrast-enhanced MRI in patients with unilateral or asymmetric audiological symptoms, together with incidental findings from imaging performed for unrelated complaints 6.

Although several cornerstones of diagnosis and therapy are recognised and shared between different centres, there are still controversies mostly related to the characteristics of tumours and patients, as well as institutional preferences. A major role is probably played by the level of global expertise and the presence of a team. Daveau et al. 7 reported that, depending on the specialist to whom the patient is first addressed to, the treatment varies significantly, ranging from observation to surgery and radiation therapy. The management of VS is thus strongly influenced by some non-objective parameters, which play a relevant role in the choice of first treatment.

The aim of the present study was to investigate the current practice patterns of VS in Italy through an anonymous questionnaire addressed to otolaryngologists and neurosurgeons.

Materials and methods

Study design and survey characteristics

A web-based, anonymous survey was administered to the members of the Italian Society of Otolaryngology, Head and Neck Surgery (SIO) and the Italian Society of Neurosurgery (SINCH) using the Google Drive platform. The survey was conceived in Italian, modifying that administered by the North American Skull Base Society (NASBS) 8, with permission. The survey was distributed between December 2018 and December 2019; after voluntarily agreeing to participate, surgeons indicated their active involvement into otoneurological/lateral skull base procedures and their surgical specialisation.

The 35-item, multiple-choice survey was divided into three sections: i) general section, investigating years of training, years of experience and volume/year of patients managed and treated; ii) section on overall practice patterns; and iii) section on management options. The full questionnaire is reported in Appendix ().

Statistical analysis

Categorical variables were presented as frequencies with percentages; data were analysed per item, so the denominator varied per question due to missing data; comparisons between variables were assessed using Chi-square or Fischer’s exact tests, as appropriate. All tests were two-tailed and statistical significance was determined by a p value < 0.05. Data were analysed using the SPSS 20 software (SPSS, IBM Company, Armonk, USA) and GraphPad Prism version 7.00 for Windows, (GraphPad Software, La Jolla California USA, ).


Demographics, experience and setting

Sixty-six subjects responded to the survey, nine women (13.8%) and 58 men (86.2%), mostly within the 50-59 year group of age (27.3%). Among them, 37 participants (56.0%), 2 females (5.4%) and 35 males (94.6%), confirmed their active involvement in the management of VS, so that their responses were taken into consideration for further analysis. Among the study group involving 25 otolaryngologists (67.6%) and 12 (32.4%) neurosurgeons, 30 (81.1%) confirmed their specific training in neurotology/lateral skull base surgery, as shown in Figure 1A. Age distribution and years of experience of the participants are reported in Figures 1B and 1C.

Most respondents, 22 (59.5%), claimed to work at a university hospital, 12 (32.4%) at hospital without academic affiliation and three (8.1%) in private practice. With regards to the volume of cases evaluated by respondents, 17 (46.0%) managed ≤ 25 cases/year, while 20 (54.0%) > 25 cases/year (5, 13.5% between 25 and 50; 10, 27.0% between 51 and 100; 5, 13.5% > 100 cases/year). There was a significant association between the number of tumours evaluated per year and type of practice setting. Higher volumes of cases (> 25 cases/year) were managed at academic settings in 72.7% of cases while lower volumes (≤ 25 cases/year) were mostly treated at hospitals without academic affiliation or in private practice in 73.3% of cases (p = 0.021). No associations were found between type of practice setting and years of experience (p = 0.279) or multidisciplinary approach (p = 0.317).

Management strategies

Eighteen respondents (50.0%) claimed to discuss patients diagnosed with VS in multidisciplinary meetings. Twenty-three (62.2%) claimed to surgically treat VS in teams where otolaryngologists and neurosurgeons are involved, and 14 (37.8%) performed surgical interventions on their own.

a. Intracanalicular VS and tumours ≤ 1.5 cm in the cerebello-pontine angle

In case of small VS, 30 respondents (81.1%) declared to prefer observation as first option, 4 (10.8%) recommended microsurgical up-front treatment and three (8.1%) radiotherapy. Considering tumour observation, the 5-year growth probability for intracanalicular VS and for small, extrameatal VS (≤ 1.5) cm was considered < 25% by 27 (75.0%) and 16 (45.7%) participants, respectively. Most respondents (28, 75.6%) believed that the best chance of retaining serviceable hearing at 10-year follow-up, is given by conservative approach.

In case of surgery, 30 participants (83.4%) declared to consider hearing preservation surgery (HPS) as a feasible strategy, while six (16.6%) do not perform this surgical option, regardless of hearing status. Given favourable tumour characteristics and contralateral normal hearing, pure tone average (PTA) ≤ 30dB and word recognition score (WRS) ≥ 70% are considered neccessary to attempt HPS by 19 respondents (51.4%), while 5 (13.5%) believed that HPS should be tried with any detectable hearing. Among different factors affecting HPS outcomes, tumour size and preoperative hearing were considered to be the strongest predictors of on hearing outcomes by 28 (75.6%) and 19 (51.3%) respondents, respectively (Fig. 2). Tumour origin (from the superior or inferior vestibular nerve), presence of cerebrospinal fluid (CSF) fundal cup, patient’s age and internal auditory canal enlargement were considered of average importance. Overall, the preferred approach for HPS was the retrosigmoid (RS) in the 61.2% of cases, for both otolaryngologists and neurosurgeons (60.0% and 58.1% respectively). More than three-fourths of respondents (77.8%) claimed to perform both the RS and middle cranial fossa approaches, depending on tumour characteristics. The chance of preserving residual hearing after HPS was estimated to be < 40% by 25 respondents (67.5%).

b. Tumours > 1.5 cm in the cerebello-pontine angle

In the case of tumours > 1.5 cm in the cerebello-pontine angle or when HPS is not the target, 19 participants (51.4%) preferred the translabyrinthine (TL) approach, 11 (29.7%) the RS approach and seven (18.9%) claimed to use both surgical corridors independently. When stratified according to specialisation of respondents, the TL approach was preferred by otolaryngologists than neurosurgeons (18, 72.0% vs 1, 8.3%, p < 0.001). On the contrary, the RS corridor was more frequently used by neurosurgeons (8, 66.7% vs 3, 12.0%, p < 0.001).

For large VS (> 3 cm), most respondents would perform a single stage surgical resection (97.3%), either via TL (51.4%) or RS (43.2%) corridors. There was a significant difference between otolaryngologists and neurosurgeons concerning the surgical approach for large VS resections. The former claimed to prefer the TL approach in 68.0% of cases, while the latter a RS approach in 75.0% of cases (p = 0.012).

Twenty-eight surgeons (75.6%) would try to achieve a total resection of large VS, unless the tumour is tenaciously adherent to the facial nerve. Six (16.2%) would perform a subtotal resection to reach adequate tumour volume for subsequent stereotactic radiosurgery/stereotactic radiation therapy (SRS/SRT), and only three (8.1%) would perform a total resection, even if it could place facial nerve function at risk. Only six (16.2%) respondents claimed to perform sub-total VS resections in large VS very frequently (more than 50% of cases). Interestingly, when stratified according to the surgical specialisation, neurosurgeons declared to perform subtotal resections more frequently than otolaryngologists would (p < 0.001).

When asked about intraoperative parameters that could threaten facial nerve function, otolaryngologists considered tumour extension and grade of adhesion at the nerve/tumour interface the most reliable (18, 75.0% vs 6, 25%, p = 0.044), while neurosurgeons more frequently relied on electrophysiological measures (6, 66.7% vs 3, 33.3%, p < 0.001). Residual tumours were preferably observed and submitted to SRS/SRT or observed and surgically treated only after documented growth by 26 (72.2%) and seven (19.5%) respondents, respectively. Early SRS/SRT (within 6 months from surgery) for residual VS was advocated by three (8.3%).

Symptom control and complications

Some questions regarded the surgical effects on symptom control. Most surgeons believe that VS surgical removal has no or unpredictable effects on tinnitus (12, 32.4%, and 20, 54.1%, respectively), while only four (10.8%) believe that surgical treatment would improve preoperative tinnitus. In case of pre-operative dizziness, 28 (75.7%) respondents suggested that surgery would lead to reduction/resolution of symptoms.

Dealing with surgical complications, the RS approach was perceived to carry the highest risk of postoperative CSF leak (19 respondents, 51.4%) by both otolaryngologists and neurosurgeons (11, 44.0% vs 8, 66.4%). Interestingly, 26 (70.3%) respondents did not avoid the RS approach despite the risk of post-operative headache.

Radiation treatment

Thirty-one (83.7%) respondents recommend SRS/SRT in less than 10 cases/year and most participants believe that radiation treatment is not indicated as a primary option for tumours measuring > 2 cm (21.6%), > 2.5 cm (35.2%), and > 3 cm (29.7%). Malignant transformation of VS after SRS/SRT is generally considered to be extremely rare by most respondents (29, 78.4%). The questionnaire was, however, not administered to radiation therapists.


Otolaryngologists and neurosurgeons directly involved in the treatment of VS are faced with a wide range of different management possibilities, ranging from observation to active treatments like surgical tumour removal or radiosurgical irradiation 9. In the absence of international accepted guidelines in this field, and lacking adequate evidence to guide VS management, the possible variability of practice mainly reflects institutional and/or surgeon’s experience biases. In the present study, the current treatment strategies for VS in Italy are reported after a nationwide survey administration among the SIO and SINCH members. Thirty-seven respondents confirmed their active involvement in VS management, 67.6% were otolaryngologists and 32.4% neurosurgeons evaluating in 54.0% of cases > 25 VS patients/year. In 2006, Goodden et al. 10 investigated on the adherence to guidelines for diagnosis and treatment of VS in the United Kingdom and Ireland, reporting that 73.0% of neurosurgeons evaluate patients with otolaryngologists. Similarly, Saeed et al. 11 obtained comparable results among otolaryngologists. In the present study, with regards to the initial assessment of VS patients, respondents were equally distributed between those who evaluate patients alone (50.0%) and those who collaborate in a multidisciplinary team (50.0%). Interestingly, considering the multidisciplinary collaboration during surgery, 62.2% of otolaryngologists and neurosurgeons claimed to work together. Although with higher rates of a multidisciplinary approach to the VS patient, the survey conducted among NASBS members 8 reflected a similar increase of percentages in multidisciplinary collaboration during the diagnostic (63.0%) and surgical phases (86.0%) of VS management.


The spread of MRI has radically changed the diagnosis and treatment of VS, which today is based at first on observation 12. Both in Italy and USA 8 the most widespread strategy for the treatment of small and medium sized VS is initial observation until tumour growth becomes evident. This policy seems to be the best choice for both otolaryngologists and neurosurgeons. In fact, the chance of growth is considered low after 5 years of observation, as shown by both the Italian and NASBS surveys 8. In this regard, Paldor et al. 13 conducted a comprehensive review of the literature considering 37 studies on > 4000 patients and reported that only 50% of tumours demonstrated a radiologically documented growth after 5 years.


The best surgical approach to treat VS, when hearing preservation is not the goal, is still a matter of debate among lateral skull base surgeons, and is reflected in the present study. A systematic literature review by Hadjipanayis et al. 14 stated that there is insufficient evidence to support the superiority of either RS or the TL approach for complete VS resection and facial nerve preservation, when serviceable hearing is not present.

In case of small to medium sized tumours, in the NASBS study 8 the TL approach was preferred, while in Italy a significant divergence between otolaryngologists and neurosurgeons came to notice. In fact, while the former preferred the TL approach (72.0%), most neurosurgeons claimed to use the RS approach (66.7%). For large VSs (> 3 cm), most North American surgeons claimed to prefer the RS approach (52.6%) 8, which is confirmed in Italy only among neurosurgeons (75.0%), as otolaryngologists preferred the TL approach (68.0%).

Facial nerve injury is one of the most frequent complications of VS surgery, particularly when the tumour reaches considerable size 15. Similar to what was reported in the NASBS study 8, our survey highlighted that most surgeons (75.6%) try to achieve total resection of the tumour mass unless it is tenaciously adherent to the facial nerve. Of note, most neurosurgeons claimed to perform subtotal resections and to rely on electrophysiological measures to demonsrate facial nerve integrity significantly more frequently than otolaryngologists, who were more prone to total resections and to rely on intraoperative assessment of tumour extension and adhesion at the nerve/tumour interface.

Considering the management of residual tumour after subtotal resections, most of the respondents (70.2%) would adopt an observation policy followed by SRS/SRT only after documented growth. This is in accordance with Taha et al. 16 reporting that, in case of important adherence with the facial nerve, a near-total tumour resection with eventual subsequent radiation therapy would be the best strategy to ensure the integrity of the nerve.

Considering symptom control, most respondents held that surgery has an unpredictable effect on tinnitus. Noteworthy, Wang et al. 17 showed that microsurgical VS resection led to Tinnitus Handicap Index reduction in up to 77% of cases. Most surgeons in Italy and in North America considered that VS surgical removal led to a reduction or even to the resolution of preoperative dizziness. Similarly, microsurgical tumour removal and trigeminal nerve decompression is considered the preferred treatment in cases with VS and associated trigeminal neuralgia 18.

Hearing preservation surgery

Both in Italy and in North America 8 in case of small tumours most of the respondents agreed that the highest chance to preserve hearing is observation. Reznitsky and Cayé-Thomasen 19 showed in a systematic review of the literature that the chance of preserving good hearing (PTA < 30 dB and WRS > 70%) after 5 years of observation is 50%. In case of HPS, according to the “Congress of Neurological Surgeons” 20, the overall probability of maintaining serviceable hearing following microsurgical resection of small to medium-sized sporadic VS is moderately low (> 25%-50%), while in case of a good pre-operative hearing level (PTA < 30 dB and WRS > 70%) the overall probability is moderately high (> 50%-75%) after surgery and progressively decreases over time.

HPS is performed by 83.4% of the Italian survey respondents. While the North American surgeons 8 preferred the middle cranial fossa approach (43.9%), Italians are more prone to use the RS corridor for HPS (61.2%). More than half of respondents, (54.1%) considered hearing class A according to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) classification the main selection criterium for HPS, while most North American surgeons (63.2%) considered more permissive preoperative hearing intervals as AAO-HNS hearing classes A and B (PTA ≤ 50 dB and SDS ≥ 50%) to perform HPS 8. There was agreement in considering both tumour size and pre-operative hearing levels to be the most important factors influencing HPS outcomes, as resulting from the Italian and American surveys 8. The recent literature demonstrated that besides the above-mentioned predictors of hearing outcomes after surgical VS removal, the presence of a fundal cap at the fundus of the internal auditory canal must also be considered relevant 20. Furthermore, Zanoletti et al. 21 investigated the predictors of postoperative hearing in HPS performed through a microscopic RS approach combined with a retrolabyrinthine meatotomy. In the attempt to better define the HPS inclusion criteria for achieving best hearing outcomes, cutoff levels for tumour size and preoperative hearing were calculated.


CFS leak is one of the most frequent complications of VS surgery, after VII cranial nerve palsy 22. While in North America 8 TL surgery was considered the approach with a higher risk of postoperative CSF leak (57.9% of respondents), in Italy both otolaryngologists and neurosurgeons considered the RS approach riskier than the TL (51.4%). A systematic review of complications conducted in 2012 found the same conclusions, demonstrating that the RS approach was significantly associated with higher risk of CSF leak than RS and middle cranial fossa approach 22.

Post-operative headache is commonly observed after the RS approach 22,23, although 70.3% of Italian and 71.6% of North American surgeons 8 did not consider this event an absolute contraindication for the approach.


Radiation treatment of VS is rarely proposed in Italy by either otolaryngologists or neurosurgeons; 83.7% of the interviewees recommend SRS/SRT in less than 10 cases/year. Regarding the cut-off size of tumours to address for SRS/SRT, there was a substantial orientation among respondents in both Italy and in North America to consider tumours between 2 and 3 cm as candidates for radiation treatment, excluding those with larger (for which the first option remains surgical) and smaller dimensions (for which the best strategy is observation). A study conducted by Golfinos et al. 24 showed that SRS for tumours ≤ 2.8 cm was associated with low morbidity and good response to treatment. One of the drawbacks of radiation therapy, i.e the possibility of malignant degeneration after treatment 25, is considered in both the NASBS and the present studies as an infrequent event.


The present study documents current practice patterns of VS care in Italy and provides the first overview on VS management of the nationwide community of otoneurosurgical, neurosurgical and skull base surgeons. Although adopted by most centres for surgical VS treatment, a multidisciplinary model of care including otolaryngologists and neurosurgeons needs to be encouraged, especially regarding the initial VS assessment and decision-making. Tumour observation and radiological growth monitoring is advocated by most interviewees in case of small VS. However, there is wide heterogeneity in experience and practices for VS care, mostly influenced by the surgeon’s different specialties. These results reflect a general lack of scientific evidence, and national guidelines will foster future research in this field.

Figures and tables

Figure 1.Characteristics of survey participants. (A) Specialisation. (B) Age distribution defined in years. (C) Years of experience in VS care.

Figure 2.Ranking of predictive factors for hearing preservation weighted by survey participants according to the perceived impact on successful hearing preservation surgery (1 = strongest predictor, 6 = weakest predictor). The average rating per item is reported between brackets.


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Nicola Quaranta

Unit of Otolaryngology, Department of BMS, Neuroscience and Sensory Organs, University of Bari, Italy

Marco Pontrelli

Unit of Otolaryngology, Department of BMS, Neuroscience and Sensory Organs, University of Bari, Italy

Sabino Ciprelli

Unit of Otolaryngology, Department of BMS, Neuroscience and Sensory Organs, University of Bari, Italy

Francesco Signorelli

Unit of Neurosurgery, Department of BMS, Neuroscience and Sensory Organs, University of Bari, Italy

Luca Denaro

Academic Neurosurgery, Department of Neuroscience - DNS, Padua University, Padua, Italy

Domenico d'Avella

Giovanni Danesi

ENT and Skull-Base Surgery Department, Department of Neurosciences, Ospedale Papa Giovanni XXIII, Bergamo, Italy

Diego Cazzador

Otolaryngology Section, Department of Neuroscience - DNS, Padua University, Padua, Italy; Section of Human Anatomy, Department of Neuroscience - DNS, Padua University, Padua, Italy; *D. Cazzador and E. Zanoletti contributed equally to this work

Elisabetta Zanoletti

Otolaryngology Section, Department of Neuroscience - DNS, Padua University, Padua, Italy; *D. Cazzador and E. Zanoletti contributed equally to this work


© Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale , 2021

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