Reviews

Vol. 46: Issue 1 - February 2026

Haemangiopericytoma and solitary fibrous tumour of the parotid gland: a scoping review

Authors

Daniele Monzani , Carlotta Liberale , Erika Segato , Valerio Arietti , Valeria Caragli , Luca Sacchetto , Riccardo Nocini , Viscardo Paolo Fabbri , Giovanna Attolini , Albino Eccher , Silvia Palma

Key words: haemangiopericytoma, solitary fibrous tumour, NAB2-STAT6 gene rearrangement, parotid gland, recurrence
DOI: 10.14639/0392-100X-A1253
Publication Date: 2026-03-09

Abstract

Salivary gland tumours represent about 3-10% of head and neck tumours, with the parotid gland being the most affected. The World Health Organization classification of these tumours is continually evolving due to their diverse histology and biological behaviour. Haemangiopericytoma (HPC) and solitary fibrous tumour (SFT) have been reclassified as a single entity characterised by NAB2-STAT6 gene rearrangement, typically presenting as slow-growing, painless masses in the parotid region, and immunohistochemistry is essential for diagnosis. This study aims to examine the clinical characteristics of these tumours to better understand their biological behaviour. Following PRISMA 2020 guidelines, we reviewed the literature using the search string (haemangiopericytoma), OR (solitary fibrous tumor) AND (parotid gland). Of the initially collected 201 papers, 49 were selected for detailed analysis, focusing on data from 53 patients, all of whom underwent surgery. Of these patients, 11.3% (n = 6) were diagnosed with malignancy, while 3 more were suspected to have malignancy. Our findings suggest that SFT morphology predominates among lesions, but malignancy is more often associated with features of HPC. Further comprehensive study is needed to gather additional data on their biological behaviour.

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Authors

Daniele Monzani - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, Verona, Italy

Carlotta Liberale - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, Verona, Italy https://orcid.org/0000-0003-4285-6862

Erika Segato - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, Verona, Italy https://orcid.org/0000-0002-7616-1180

Valerio Arietti - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, Verona, Italy. Corresponding author - valerio.arietti@gmail.com

Valeria Caragli - Otolaryngology and Audiology Unit, University of Modena and Reggio Emilia, Modena, Italy https://orcid.org/0009-0005-7112-0282

Luca Sacchetto - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, Verona, Italy https://orcid.org/0000-0003-3880-4998

Riccardo Nocini - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, Verona, Italy https://orcid.org/0000-0002-7616-1180

Viscardo Paolo Fabbri - Department of Laboratory Medicine and Surgical Anatomy, Pathology Unit, AOU Policlinico Modena, Italy

Giovanna Attolini - Department of Laboratory Medicine and Surgical Anatomy, Pathology Unit, AOU Policlinico Modena, Italy

Albino Eccher - Department of Laboratory Medicine and Surgical Anatomy, Pathology Unit, AOU Policlinico Modena, Italy; Section of Pathology, Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, University Hospital of Modena, Modena, Italy

Silvia Palma - Department Audiology Primary Care, Ausl, Modena, Italy https://orcid.org/0000-0002-5521-4343

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Copyright

Copyright (c) 2026 Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale

How to Cite
Monzani, D., Liberale, C., Segato, E., Arietti, V., Caragli, V., Sacchetto, L., Nocini, R., Fabbri, V. P. ., Attolini, G. ., Eccher, A., & Palma, S. . (2026). Haemangiopericytoma and solitary fibrous tumour of the parotid gland: a scoping review. ACTA Otorhinolaryngologica Italica, 46(1), 12–22. https://doi.org/10.14639/0392-100X-A1253
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