Inverted papilloma of the frontal sinus is a challenging disease. Given its rarity, only small case series are present in the literature. The objectives of the present study are to review our experience in the surgical management of inverted papillomas involving the frontal sinus and to propose a practical algorithm for selecting the most appropriate approach. Data on patients affected by inverted papilloma involving the frontal sinus and surgically treated between 2002 and 2016 were collected. The type of involvement of frontal sinus and extent of surgery performed (endoscopic endonasal, external or combined approaches) were analysed. A brief review of consistent literature was also carried out. Forty-seven consecutive patients were treated using an exclusive endoscopic endonasal approach (EEA) in 18 cases, while a combined endonasal with external osteoplastic approach was required in 29 cases. Most patients (29/47, 62%) had been treated previously, mainly by an endoscopic approach. A single intraoperative complication occurred (1/47, 2%), i.e. cerebrospinal fluid (CSF) leak, that was successfully repaired intraoperatively without any consequences. Recurrences were observed in only 2/47 cases (4%) after a mean follow-up of 43 months (range, 12-137). The management of inverted papilloma involving the frontal sinus requires great expertise and the surgical technique should be tailored to the site of attachment of the tumour, its extension and the anatomical conformation of each frontal sinus. The encouraging results obtained in this case series support the use of this practical treatment algorithm.


Inverted papilloma is the most common epithelial benign tumour of the nose and paranasal sinuses, accounting for approximately 0.5 to 4% of all sinonasal neoplasms 1. It arises from the Schneiderian mucosa and grows into the underlining stroma with a typical endophytic pattern. Though considered a benign lesion, this tumour is characterised by a well-known tendency to relapse in case of incomplete removal 2 and by a variable association with squamous cell carcinoma, either synchronous or metachronous 1 3 4. These features, along with frequently associated bony alterations (erosion or osteosis), make inverted papilloma an unpleasant lesion, which needs to be approached carefully and excised thoroughly.

The frontal sinus is an anatomically challenging region, both functionally and aesthetically: its anterior wall gives shape to the forehead, while its posterior wall encloses the frontal lobes, i.e. the ventral edge of the anterior cranial fossa. Inverted papilloma involving the frontal sinus represents only 2.5% of all cases 5 and has been traditionally managed through external transcranial approaches 3. Nowadays, the endoscopic endonasal technique is considered the gold standard approach for the treatment of sinonasal Schneiderian papillomas 6, without the common post-surgical complications of the external approaches, let alone reduced discomfort for patients and time of hospitalisation 7. However, endoscopic access to the frontal sinus can still be challenging because of its anatomy and unfavourable position, requiring curved instrumentation and the necessity to control any of its recesses when dealing with either benign or malignant tumours.

To date, there is still debate about the best technique to address inverted papillomas in this site and no definitive guidelines exist. The aims of this study are to share our experience in the management of inverted papilloma arising from or extending into the frontal sinus, and to propose a practical algorithm for the surgical management of these lesions. The different surgical procedures available and their specific indications are also discussed and reviewed along with the small amount of data present in the literature.

Materials and methods

Study design

A retrospective review of a single institutional database on inverted papillomas arising from or extending to the frontal sinus, treated surgically between July 2002 and December 2016, was performed. Approval was obtained from the Insubria Board of Ethics. The following data were collected: sex, age at intervention, side involved, symptoms at presentation, previous treatments, origin and extension of disease, type of surgery, early and late complications, histology, time of follow-up and recurrence. Inclusion in the study required a minimum follow-up of 12 months.

Pre-operative work-up

A plain CT scan and/or a contrast-enhanced MRI were obtained in all cases. All patients were also submitted to endoscopic endonasal evaluation to identify intranasal extension of the lesion. A biopsy under local anaesthesia was always performed after imaging evaluation to confirm diagnosis and assess for possible coexistence of carcinomatous foci.

Surgical strategies

All surgical procedures were performed under general anaesthesia. The entity of dissection was modulated in relation to the site and extent of the lesion defined by preoperative imaging and intraoperative findings. Informed consent about the possibility of intraoperatively switching from an endoscopic to a combined endoscopic-transcranial approach was obtained in all patients, especially for those with massive frontal sinus and/or supraorbital cell involvement. When present, the naso-ethmoidal and maxillary sinus component of the inverted papillomas were treated according to the three different types of endoscopic procedures (Types 1, 2, 3), which have been extensively described in a previous publication (Table I) 8. An endoscopic frontal sinusotomy (type I, IIA, IIB, or III) according to Draf 9 was performed in all cases.

Whenever a mucosal involvement inside a supraorbital cell extending far laterally over the orbital roof was identified, resection was performed, or anyway attempted as first step, using an endoscopic endonasal orbital transposition approach 10, which has become common practice in the last decade. In case of massive involvement of the frontal sinus, particularly when highly pneumatised, an osteoplastic flap (OPF) using a bicoronal approach was planned. Inverted papillomas encroaching and possibly crossing the anterior or posterior bony wall of the frontal sinus, with intracranial extension or subcutaneous involvement, or inverted papillomas associated with squamous cell carcinoma, should be treated using traditional transcranial approaches (Riedel’s technique and its modifications or classic craniofacial resection) 11 12 . The practical algorithm used to plan the surgical resection is summarised in Figure 1. Frozen sections were extensively used intraoperatively to ensure a free-margins resection. Based on the radiological and surgical findings, all tumours were staged according to the system of Krouse 13.


Patients were followed after surgery with serial endoscopic endonasal evaluations. Irrigations with saline solution (twice daily) were recommended for at least 1 month. Post-operative contrast-enhanced MRI scans were performed at 6 months after surgery and thereafter in the presence of scar tissue obscuring the visualisation of the site of origin of the lesion (every 6 months for the first 2 years and then once a year for the following 3 years). Postoperative MRI evaluation was scheduled in case of clinical or endoscopic suspect of local recurrence.


Patient population

Forty-seven patients fulfilled the inclusion criteria and were included in the study. There were 34 males and 13 females (M:F = 2.5:1). Age at surgery ranged from 26 to 78 years (mean 57 years). Frontal sinus was the site of origin of the tumour in 16 cases; the remaining patients had the frontal sinus involved as extension from the anterior ethmoid (27 cases, including frontal recess in 2 cases) and posterior ethmoid (4 cases). Bilateral involvement of the frontal sinus was present in 9 patients (20%), in 5 of whom the tumour originated from the frontal sinus. Nasal obstruction was the most common symptom (32 patients, 67%), followed by headache, either as the main (7%) or associated complaint (31%). Nasal discharge was present in only 6 patients (14%) and anosmia in 3 (7%). Four patients (8%) were asymptomatic and diagnosed incidentally during head imaging for other causes.

Before treatment in our tertiary care referral centre, 30 patients had been already treated surgically elsewhere, almost all with an exclusive endoscopic approach (29 cases) except for one case treated with an external Caldwell-Luc procedure. Prior to surgery, the available imaging was a combination of CT scan and contrast-enhanced MRI in 38 cases (80%), CT scan alone in 5 cases (10%) and only MRI in 4 cases (9%). All clinical and demographic data are summarised in Table II.

Surgical procedure

Patients were divided in two groups: one group included all patients treated with an exclusive endoscopic endonasal approach, while the other one included all patients treated with a combined endoscopic-OPF approach. No case in the present series fulfilled the requirements for a classic or modified Riedel’s procedure or for a classic craniofacial resection, hence these approaches were never performed.

A purely endoscopic endonasal approach (EEA) was used in 18 patients (38%): Type 1 resection was performed in 11 cases, Type 2 in 2 cases and Type 3 in 5 cases. In this group of patients, the frontal sinus was the site of origin of the disease in 3 cases (3/18, 17%). In 8 cases an endoscopic orbital transposition was performed in order to resect a lesion located in the supraorbital recess (Fig. 2). The frontal sinusotomy was a Draf type 1 in 2 cases (2/18, 11%), a Draf type 2a in 3 cases (3/18, 17%), a Draf type 2b in 11 cases (11/18, 61%) and a Draf type 3 in 2 cases (2/18, 11%). Figure 3 shows pre-operative extension and post-operative results of a patient successfully treated with an EEA. No case required conversion from a purely endoscopic endonasal procedure to an OPF.

Conversely, a combined EEA with OPF was necessary in 29 patients (62%), of whom 11 had the frontal sinus as a primary site of origin of the tumour (13/29, 45%) (Fig. 4). A Draf type 2b frontal sinusotomy was performed in 12 cases (12/29, 41%), while a Draf type 3 was performed in the remaining cases (17/18, 59%). Figure 5 shows pre-operative extension and post-operative results of a patient treated with combined EEA-OPF resection.

To note, choice of the most appropriate approach was driven not only by the origin site, but also by intraoperative evidence of diseased mucosa in the frontal sinus. Table III illustrates the different approached used, based on the sites encroached by the lesion. A combined EEA with OPF was more often required if the lesion involved either the anterior or posterior walls of the sinus or the supraorbital recess or multiple sites.

Histology and classification

Final histology was consistent with inverted papilloma in 46 cases, while in one case it required a combined EEA with OPF in whom an oncocytic papilloma was diagnosed. Variable levels of dysplasia were observed within the surgical specimens: mild dysplasia in 3 cases, moderate in 5 cases and severe in 1 case.

In one patient, a 64-year-old female, a synchronous invasive squamous cell carcinoma was identified. The inverted papilloma originated in the left frontal sinus and extended in the ethmoidal compartment and nasal fossa. A combined EEA with OPF approach was used. Final histology showed focal invasive squamous cell carcinoma, moderately differentiated, involving the vegetating nasal portion of the lesion, without infiltration of the ethmoidal and frontal components. This case was discussed post-operatively during a multidisciplinary meeting and neither revision surgery nor adjuvant radiation therapy was deemed necessary.

According to Krouse staging of disease 13, involvement of the frontal sinus defines tumour as T3, and thus this was the final stage for all patients except for the one with associated synchronous carcinoma, defined as T4.

Complications and follow-up

In a single occasion, during a purely endoscopic endonasal approach, an intraoperative CSF leak occurred at the level of the left olfactory fissure, and thus a skull base reconstruction with a free graft of nasal mucoperiosteum placed overlay was performed. Neither recurrent leakage nor further complications were observed.

During follow-up (mean, 43 months; median, 32 months; range, 12-137 months), 17 patients (35%) presented with frontal stenosis, most of the time symptomless (12/17, 71%), 2 other patients (4%) with mucoceles and 1 additional patient (2%) with epiphora (Table IV). Of 17 cases with frontal stenosis, the frontal sinusotomy performed during resection of the IP was a Draf type 1 and a Draf type 2a in 1 case each, a Draf type 2b in 7 cases and a Draf type 3 in 8 cases. Both cases with mucoceles and 5 cases of frontal stenosis required revision surgery using an endoscopic endonasal approach. The patient complaining of epiphora was successfully treated with endoscopic dacriocystorhinostomy.

During follow-up, two patients (4%) experienced recurrence of disease and were consequently re-operated at, respectively, 8 and 40 months after the first surgical procedure. The first presented with inverted papilloma originating in the right posterior ethmoid and extending into the frontal sinus and was submitted to an EEA. He later developed a recurrence in the frontal sinus, which required a combined EEA with OPF. The second patient initially presented with inverted papilloma arising from the anterior wall of the right frontal sinus and extending into the ipsilateral ethmoidal compartment and maxillary sinus, and she was submitted to a combined EEA with OPF. She later developed frontal stenosis and complained of unbearable frontal headache, so she underwent revision surgery through a combined EEA with OPF: intraoperatively, suspicious tissue was removed from inside the frontal sinus and was compatible with IP at final histology. After 44 and 100 months of follow-up, respectively, these patients are alive without evidence of disease.

To note, the patient with diagnosis of synchronous squamous cell carcinoma was followed with stricter clinical endoscopic and radiological exams with contrast-enhanced MRI evaluations every 6 months and a total body CT scan once per year. She is currently alive without recurrence of disease after 96 months of follow-up.


As already pointed out throughout the literature 2 8 , resection of inverted papilloma should be particularly focused on the attachment site of the lesion: removal of the mucosa together with the periosteal layer followed by the drilling of the underling bone is crucial to avoid recurrences. This is the reason why the pre-operative identification of the tumour’s site of attachment on radiological imaging is paramount. Endoscopic endonasal eradication is relatively accessible whenever the tumour involves the maxillary, ethmoid or sphenoidal sinuses; conversely, it can become difficult if the frontal sinus mucosa is interested by the tumour and the lesion does not simply vegetate inside the sinus. This is particularly true in case of extensive involvement of the sinus, which may preclude complete visualisation of the lesion and reduce the manoeuvrability of instruments.

Recently, a novel technique has been described to expand the EEA to lesions occupying the far lateral recess/supraorbital recess of the frontal sinus, the so-called endoscopic orbital transposition. This technique, based on a superomedial orbital wall decompression with preservation of the periorbital integrity, allows lateral dislocation of the orbital content, making the surgeon able to reach further in the lateral recess, thanks to a combined Draf type IIb or Draf type III frontal sinusotomy. As a consequence, inverted papilloma arising in the frontal sinus, laterally to a sagittal plane passing through the lamina papyracea, may no longer be considered as an absolute contraindication to EEA.

However, when the site of attachment is located on the superior, lateral, or anterior wall of the frontal sinus as well as in case of massive involvement of the frontal sinus mucosa or in case of a highly-pneumatised frontal sinus, endoscopic endonasal resection is highly challenging, as already stated by other authors 14 15 . In such cases, extended endoscopic approaches allow debulking of the tumour and identification of the sites of tumour attachment, but they may be not sufficient to eradicate the lesion; hence, open approaches are usually necessary, namely an osteoplastic flap (OPF) or an endoscopic frontal trephination (EFT). Of note, despite being mandatory to obtain pre-operative plain CT scan and gadolinium-enhanced MRI to evaluate the origin and extension of the lesion and to plan the most suitable surgical approach, the final tumour encroachment can be clearly assessed only intraoperatively, aided by frozen sections, so that any possible site of attachment may be eradicated.

Recently, a new technique based on a combined endoscopic endonasal and transpalpebral orbitofrontal minicraniotomy has been proposed by Albathi et al. 16. Though innovative, this experience is very limited, with only 4 cases described, and thus it is definitely too early to draw any conclusions about its efficacy and long-term outcomes.

At present, in cases unfit for endonasal endoscopic eradication, we prefer to use the OPF because it offers better aesthetic results, allows complete access to the frontal sinus and is safer, since it can be performed using ENT magnetic navigation systems, as previously described 17. At the end of this procedure, the bone flap is replaced and fixed with screws, without obliteration of the sinus. Whenever an OPF was required, this was carried out as a single stage operation, combining it with endoscopic endonasal surgery to simultaneously rehabilitate natural frontal sinus drainage. There is no need, in our opinion, to stage a second surgery as suggested by other studies 14. Moreover, no major intraoperative or postoperative complications occurred in our series: this is consistent with the learning curve and acquired experience of the surgeons as well as the evolution of the technique since the first review was published 18. Other authors reserve OPF for extreme cases and propose to use EFT, which is exploited to introduce instruments or endoscope 15. However, in that paper, the non-negligible recurrence rate (22%) and associated complications [CSF leak in 1 of 5 cases (20%) with EFT] 15 suggest a limited use for this technique, and only in very well selected cases.

Inverted papilloma with intracranial extension is a rare finding with only 17 cases described in English literature and is usually seen in recurrent cases 11 12 . Anterior cranial fossa invasion occurs after destruction of the posterior table of frontal sinus or the roof of the nasal cavity. Data from the literature suggest that this uncommon condition can be effectively managed by craniofacial resection (CFR) 11 12 . Although no cases in our series required such an aggressive approach, this surgical option has been included within the rationale for management of these challenging tumours (Fig. 1).

Several case series analysing surgical management of frontal sinus inverted papilloma have been published recently 19-23, although numbers are obviously poor because of the rarity of the disease and the uncommon location. Table V provides a brief review of the English literature on articles concerning treatment of inverted papilloma of the frontal sinus from 2002 onwards.

Recently, Walgama et al published a review of the literature that was unable to demonstrate the superiority of one surgical approach over the others for successful removal of inverted papilloma of the frontal sinus 24. The authors concluded that surgeons should be able to handle all different types of techniques and to be ready to convert from endoscopic to external approaches whenever dictated by intraoperative findings, possibly with a single-stage operation. The same review showed an overall recurrence rate of 22.4% which was lower in case of origin of the lesion from the posterior wall and in case of secondary disease, though without any statistical significance (p = 0.051 and p = 0.074, respectively). Posterior-wall lesions are probably the most accessible ones, and thus radical resection is achieved more often. As far as secondary lesions are concerned, this trend can be probably explained by a more aggressive approach adopted due to the natural history of the disease. We are not able to infer any data from our recurrent cases (2/47, 4%) because of insufficient statistical power and completely different features of the patients (combined approach for an IP originating from the frontal sinus; EEA for an IP originating from the anterior ethmoid). Of note, both patients presented with persistent/recurrent IP after being submitted to an endoscopic endonasal procedure at another centre, thus underlying the role of residual scar tissue and distorted anatomy in hindering the revision surgery, as already stated by other authors 20.

Globally, the recurrence rate of 4% reported in our study is similar to what is described in more recent studies 20. When considering only papillomas originating from the FS, the recurrence rate is 1/16 (6%), which is definitely lower than the above-cited review 24 or more recent papers 25. We believe that these data strongly support the efficacy and safety of the surgical algorithm herein proposed for the management of inverted papilloma involving the frontal sinus. As a general rule, we prefer an exclusively endoscopic endonasal approach whenever feasible, in order to decrease morbidity for patients and reduce hospitalisation time 26. However, it is our opinion that some cases pose an absolute contraindication to pure EEA, which would result in incomplete resection of disease. Current contraindications for an EEA in the surgical management of frontal sinus inverted papilloma 10 are summarised as follows:

  • small antero-posterior diameter of the frontal sinus (< 1 cm) and small interorbital distance;
  • erosion of the posterior wall of the frontal sinus with intracranial extension;
  • extension of the lesion through the anterior frontal plate;
  • massive lateral supraorbital attachment of the lesion in laterally-pneumatised frontal sinus;
  • attachment of the tumour to the anterior wall or to the upper half of the posterior wall of the frontal sinus;
  • massive involvement of the mucosa of the frontal sinus and/or of supraorbital cell;
  • histological evidence of SCC in IP at pre-operative biopsies or intraoperatively with frozen sections;
  • presence of abundant scar tissue from previous surgery or relevant post-traumatic anatomic changes of the frontal bone.
  • Conclusions

    To the best of our knowledge, this is the largest single-centre case series of inverted papilloma involving the frontal sinus, either as origin or extension. The practical algorithm for surgical treatment planning of such lesions is based on the site of attachment of the lesion and the anatomical conformation of the frontal sinus, and is supported by a very low recurrence rate (4%) and minimal complications observed.

    EEA should be used whenever feasible and able to obtain radical resection of inverted papilloma in the frontal sinus. On the other hand, a combined approach with an OPF has to be used whenever dictated by the localisation of the tumour, and particularly by its sites of attachment inside the frontal sinus, even when the point of origin is situated outside of the sinus (i.e. in the ethmoidal compartment). To note, a new approach to the far lateral frontal sinus, the so-called endoscopic orbital transposition 10, has lately changed our paradigm toward a totally endoscopic endonasal tumour removal in selected cases.

    In conclusion, the present study emphasises that what really matters is complete tumour eradication, possibly using the least invasive approach for the patient. Endoscopic endonasal techniques have drammatically changed the approach to inverted papilloma, although the endoscope remains a very useful tool even if not the solution for every case.

    Figures and tables

    Fig. 1..

    Fig. 2..

    Fig. 3..

    Fig. 4..

    Fig. 5..

    Table I..

    Type of endoscopic procedure Surgical steps
    1 Anterior and posterior ethmoidectomy, sphenoidotomy, large middle antrostomy, partial or complete middle turbinectomy, frontal sinusotomy (type I, IIA, IIB, or III according to Draf’s classification 9 in relation to the extent of disease)
    2 Anterior and posterior ethmoidectomy, sphenoidotomy, medial maxillectomy, partial or complete middle turbinectomy, frontal sinusotomy (type I, IIA, IIB, or III according to Draf’s classification 9 in relation to the extent of the disease) (± naso-lacrimal duct section)
    3 Anterior and posterior ethmoidectomy, sphenoidotomy, endonasal Denker operation with naso-lacrimal duct section, complete inferior and middle turbinectomy, frontal sinusotomy (type I, IIA, IIB, or III according to Draf’s classification 9 in relation to the extent of disease)
    Summary of surgical steps in the 3 types of endoscopic procedures 8 .

    Table II..

    Number of patients 47
        Male 34 72%
        Female 13 28%
    Mean age (range) 57 years (26-78)
    Side of lesion
        Right 21 45%
        Left 17 36%
        Bilateral 9 19%
    Site of origin
        Frontal sinus 16 34%
        Ethmoid 31 66%
    Previous surgery
        None 17 36%
        Endoscopic 29 62%
        External 1 2%
        CT 5 10%
        MRI 4 9%
        CT+MRI 38 81%
    Type of surgery
        EEA (with OT) 18(8) 38% (17%)
        EEA + OPF 29 62%
        Inverted papilloma 46 98%
        Oncocytic papilloma 1 2%
    Associated histology
        None 37 79%
        Mild dysplasia 3 6%
        Moderate dysplasia 5 11%
        Severe dysplasia 1 2%
        Carcinoma in situ
        SCC 1 2%
        No 45 96%
        Yes 2 4%
    Mean follow-up (range) 43 months (12-137)
    Clinical and demographic data of patients.

    Table III..

    Sites of attachment EEA EEA + OT EEA + OPF Total
    PW 3 7 10
    AW 1 4 5
    MW 1 1
    LW 1 1
    SR 8 10 18
    FR 5 2 7
    PW+FR 1 1 2
    PW+SR 1 1
    PW+LW 1 1
    AW+SR 1 1
    Total 10 8 29 47
    Sites of attachment of IP inside the frontal sinus and surgical technique adopted.

    Table IV..

    Early complications Late complications
    EEA (18) 1 CSF leakage (1/18, 6%) 6 frontal stenosis (6/18, 33%) 1 epiphora (1/18, 6%)
    EEA + OPF (29) 11 frontal stenosis (11/29, 38%) 2 mucoceles (2/29, 7%)
    Total (47) 1 (1/47, 2%) 20 (20/47, 43%)
    Early and late post-operative complications according to surgical technique.

    Table V..

    Author Year Total cases Cases with FS involvement Type of surgery Results No. of relapses Type of surgery for relapse Status Follow-up (months)
    Present study 2018 47 47 19 EE 28 combined 100% CR 2 2 OPF 100% NED 43
    Albathi 16 2018 4 4 EE + TrP 100% CR 0 100% NED 24
    Adriansen 20 2015 20 20 EE 100% CR 2 EE 100% NED 42
    Ungari 27 2015 35 5 FS 13 FE OPF 100% CR 2 2 OPF 100% NED > 12
    Pagella 28 2014 73 2 FS 8 FE EE 100% CR 0 100% NED 58
    Sciarretta 29 2014 110 7 FR 4 FS EE 100% CR 1 FR 1 FS 1 EE (FR) 1 OPF (FS) 100% NED 56.7
    Kim 30 2012 578 22 (origin) 10 EE 8 combined 4 external 100% CR 6 N/A N/A 41
    89 (extension) 59 EE 20 combined 10 external 24
    Gotlib 21 2012 2 2 EE 100% CR N/A N/A 50% NED 50% N/A 12
    Walgama 24 2012 49 49 31 EE 13 OPF 5 EFT 100% CR 11 8 EE 1 EFT 2 OPF 100% NED 27
    Lian 31 2012 26 1 EE 100% CR N/A N/A 100% NED 28.2
    Kamel 32 2012 119 6 EE 100% CR 0 100% NED 27
    Bathma 33 2011 13 4 FR EE 100% CR 2 § EE 100% NED 40
    Lombardi 34 2011 212 11 EE 100% CR 2 1 EE 1 OPF 100% NED 53.8
    Dragonetti 35 2011 84 3 FS 5 FR 6 EE 2 OPF 100% CR 1 (FR) OPF 100% NED 39.5
    Gras-Cabrerizo 36 2010 79 8 (extension) 5 EE 3 external 100% CR N/A N/A N/A > 12
    Sham 37 2009 56 3 1 EE 2 ExFS + 100% CR 3 2 ExFS 1 ExFS + Lothrop 89% NED 11% DOC 84
    Yoon 15 2009 18 18 2 OPF 5 EFT 100% CR 4 3 EE 1 EFT 100% NED 36.6
    Eweiss 22 2009 4 4 EE 100% CR 1 OPF 100% NED N/A
    Landsberg 38 2008 30 2 EE 50% CR 50% PR 1 50% NED 50% AWD 40
    Mackle 39 2008 55 1 OPF 100% CR N/A N/A N/A > 36
    Zhang 23 2008 9 9 * EE 100% CR 0 – 1 OPF 100% NED 15.1
    Sautter 19 2007 5 5 4 EE 1 EFT 100% CR 0 100% NED 16.8
    Mortuaire 40 2007 65 3 N/A 100% CR 1 External N/A 28
    Woodworth 41 2007 110 10 FR 9 FS 10 EE 5 OPF 2 EFT 2 EE + Lynch 100% CR 8 5 EE 1 EFT 1 EE + OPF 1 EE + Lynch 100% NED 40
    Minovi 42 2006 87 13 4 EE 9 OPF 100% CR N/A N/A 100% NED 74
    Katori 43 2005 39 2 (origin) 8 (extension) EE, external 100% CR 5 # EE, external N/A 35
    Dubin 14 2005 18 6 2 EE 1 OPF 3 EE + OPF 67% CR 33% PR 3 ° 2 EE 1 OPF 83% NED 17% DOC 13.3
    Jameson 44 2005 18 1 FS 1 FR 1 OPF 1 EE 100% CR 0 100% NED 29
    Wolfe 45 2004 50 3 FS 2 FR 3 EE 1 OPF 1 Lynch 100% CR 0 100% NED 31.1
    Review of English literature on surgical treatment of frontal sinus inverted papilloma (2002-2017).