Published: 2022-06-30

Silent sinus syndrome: systematic review and proposal of definition, diagnosis and management

Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, Milan, Italy
Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, Milan, Italy
Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
silent sinus syndrome maxillary atelectasia enophthalmos imploding antrum syndrome silent sinus syndrome management


Silent Sinus Syndrome (SSS) is a rare disease consisting of a collapse of maxillary sinus walls with concomitant orbital floor descent. Due to its rareness, the literature highlights some confusion on its definition, diagnosis and management. A PRISMA-compliant systematic review was performed on SSS with focus on definition, diagnosis and therapeutic management. Twenty-eight studies were selected, with 276 patients evaluated. The analysis revealed that the leading definition of SSS includes evidence of both enophtalmos and maxillary atelectasia. Although the definition of SSS accepts only spontaneous sinus collapse, the presence of sinonasal diseases and history of facial trauma are starting to be included in the criteria. Most studies (n = 21) considered CT scans satisfactory for diagnosis of SSS, while 7 also performed MR. The majority of SSS were successfully treated with isolated functional endoscopic sinus surgery (n = 17), sparing orbital reconstruction as a rescue procedure in case of non-satisfactory long-term resolution of signs. Although the literature is starting to coordinate on diagnosis of SSS, our review revealed the necessity of consensus on its definition and management.


Silent sinus syndrome (SSS) or imploding antrum syndrome is a very rare condition, usually consisting of asymptomatic spontaneous collapse of the sinus walls and floor of the orbit 1. Due to its rarity, the literature has often highlighted the confusion around its definition, diagnosis and proper management.

The aetiology of SSS remains controversial. Patients typically deny preexisting sinus disease or orbitofacial trauma. Most authors postulate that collapse of the inferior orbital wall is induced by negative pressure generated by resorption of gas after a natural ostium occlusion that may occur during the first or second decade of life 2,3.

Clinical appearance usually consists in asymptomatic enophthalmos and altered facial appearance. Nevertheless, diplopia, sinusitis, rhinorrhoea, post-nasal drip, facial pressure, or pain may also be present 1,4.

SSS and Chronic Maxillary sinus Atelectasia (CMA) are terms which have been used interchangeably; the latter can be defined as a persistent and progressive decrease in maxillary sinus volume secondary to inward bowing of the antral walls 5.

Some authors define CMA as SSS, while others sustain that the two are separate clinical entities 6,7. For example, according to Ende et al, it is possible to consider three stages of CMA: the last, group III, is defined by clinical facial deformity with the onset of ocular disturbances, and may be also defined as SSS 8. Brandt et al. also argued that SSS should be considered a subtype of CMA 9.

The original definition of SSS dates to 1994 and included only spontaneous enophthalmos not associated with prior trauma or surgery 2. Nevertheless, many authors have started accepting wider inclusion criteria involving more aetiologies (idiopathic, post traumatic, and iatrogenic) and sustain that they should be included in the definition of SSS 10.

Treatment is also a subject under continuous re-evaluation. At first, surgical treatment consisted in Caldwell-Luc sinus surgery with inferior meatotomy and concurrent transconjunctival repair of the orbital floor. In 1993, Blackwell et al. described endoscopic maxillary antrostomy (FESS: functional endoscopic sinus surgery) in conjunction with a transconjunctival orbital floor repair (OR) in three patients and reported resolution of maxillary disease on follow-up and no recurrence of enophthalmos 1.

Nowadays, the leading treatment of SSS, in order to restore the natural ventilation of the maxillary sinus, appears to be FESS 11. Instead, the main controversy in literature remains the necessity and timing of the orbital floor reconstruction via a subconjunctival approach. Some authors prefer a one-stage approach, with endoscopic antrostomy and reconstruction of the orbital floor performed at the same time 10,12. Others believe that a two-stage approach is more convenient, with a delay between antrostomy and the orbital reconstruction of 6 months 13. Still others consider FESS alone to be the best choice of therapy with less invasiveness and satisfactory results, with no need of OR 6.

To shed light on these controversies, we performed a systematic review of the literature on SSS, with particular focus on definition, diagnosis and surgical approach.

Materials and methods

A PRISMA-compliant systematic literature review 14 was carried out in December 2020 on the Web of Science, PubMed and Scopus databases, using a search strategy for “(Silent Sinus) AND (Maxillary)” and “(Silent Sinus Syndrome) AND (Maxillary)”.

We included studies focused on SSS with the following criteria.

Inclusion criteria

  1. Age 1-100 years.
  2. Silent sinus syndrome (SSS).
  3. Chronic maxillary atelectasia (CMA).

Exclusion criteria

  1. Studies whose main purpose was unrelated to SSS characteristics and management.
  2. No human patients involved.
  3. Language other than English, Italian, French, German and Spanish.
  4. Article accepted but not published.
  5. Article type: case reports with less than 3 patients, reviews, comments, letters to the editor, book chapters.

Population, Intervention, Comparison, Outcomes, and Study (PICOS) criteria

PICOS criteria 15 for the present review were as follows:

  1. Patients with CMA or SSS diagnosis.
  2. Intervention: evaluation of definition, diagnostic criteria and treatment.
  3. Comparison: comparison of different definitions, diagnosis and therapeutical options (FESS + OR, FESS alone, OR alone, antibiotic therapy, wait & see).
  4. Outcome: proposal of shared definition, diagnostic criteria and treatment.
  5. Study design: Retrospective case studies and case series (more than 3 patients) were enrolled in the review.

Data extraction and quality assessment

Two of the authors (CR and CP) independently screened the retrieved studies based on title and abstract; when uncertainty existed in the abstract evaluation, we retrieved and assessed the full text. After completion of all searches, duplicates were removed. Evaluation through full-text screening was then carried out. Critical appraisal led to the selection of 28 studies (Fig. 1). Both retrospective and prospective studies were included, while case reports and small case series were excluded because of their intrinsically lower level of evidence (the minimum number of patients was arbitrarily set at 3). Published reviews on SSS were similarly excluded, but their reference list was reviewed to identify possible additional studies. A manual search in the reference lists of these articles was performed to identify potentially relevant papers missed during the database search. Differing opinions were resolved by consensus between the two authors. Data extracted and analysed included study design, sample size, mean patient age, diagnostic criteria, associated factors, instrumental diagnosis, surgical approach and timeline, outcomes, complications and follow-up time.


The systematic review retrieved 28 original articles 3,4,6,7,10-13,16-19,21,23-37. Twenty-one were retrospective case studies (RCS), while 7 were case reports reporting at least 3 cases. A total of 276 patients were evaluated with a mean of 9.8 cases per study (range 3-57). Mean age was 40.4 years, although 3 papers did not report the age of participants (Tab. I). There was a wide variety of diagnostic criteria among studies (Tab. II). The most frequently required findings for diagnosis were evidence of enophthalmos (En) (25 studies), maxillary atelectasia (MA) (23 studies) and hypoglobus (15 studies), while post-traumatic, facial asymmetry and diplopia evidence were less required (respectively, in 3, 3 and 1 studies) as seen in Table II. Moreover, 7 studies did not directly define diagnostic criteria, which were extrapolated from the manuscript.

Nine studies included patients with sinonasal symptoms; 6 included post-traumatic cases, and 1 had post-surgical SSS (Tab. I). Twenty studies diagnosed SSS with CT alone, while 7 performed both CT and MR imaging. One study did not define what imaging was performed (Tab. I).

Surgical approaches consisted in combined FESS and OR in 72 patients, mostly in a one-step surgery. Four studies performed both types of timing-choices (one step or two steps 6 months apart), deciding according to the individual case. FESS alone was performed in 116 patients; other less common therapies were a wait & see approach (57 patients), OR alone (8 patients) and antibiotic therapy (1 patient) (Tab. III). A study by Khon et al. did not define their therapeutical approach in the 22-patient case series 29.

All patients had clinical resolution (CR) or clinical improvement (CI). Only Lin and Brown reported 2 patients who had FESS surgery alone that did not resolve enophthalmos, who then underwent subsequent OR 13,16. Complications are reported in Table I.


SSS is a relatively rare disease that most ENT specialists and ophthalmologists know as an entity, but the sporadic evidence leads to ambiguity on many of its aspects, from definition, to diagnostic criteria to treatment.


Our systematic review revealed that among the 28 studies evaluated, the most required diagnostic criteria were evidence of enophthalmos (25 studies) and maxillary atelectasia (MA) (23 studies), with 21 requiring both signs. Hypoglobus observation follows as essential criteria in 15 studies, also with evidence of orbital floor remodeling at CT scans (11 studies) and the absence of sinonasal diseases (10 studies) (Tab. II).

Therefore, even if there is much misunderstanding around the definition of SSS, it is possible to assume that most authors agree in having both enophthalmos and MA as necessary criteria. Only 2 studies required only MA in the absence of enophthalmos, considering CMA and SSS as a same entity 4,17.

Post-traumatic silent sinuses were originally excluded from the definition of SSS 18,19, and some recent papers continue considering post-traumatic cases not definable as SSS due to their lack of spontaneous development 10,20.

Nevertheless, a retrospective analysis of 6 cases and literature review showed how traumatic SSS management follows the same principles as for spontaneous SSS 21. In fact, our analysis revealed that recent papers started to include enophthalmos with MA secondary to traumatic events in the group of SSS, explaining that clinical and radiological presentations are comparable, as well as surgical treatment 13,21,22.

Moreover, the association of SSS with sinonasal symptoms is debated. Ten studies considered the evidence of sinonasal symptoms as an exclusion criterion because MA secondary to chronic sinusitis with sinus dysventilation and sinonasal symptoms is, by those authors, considered as CMA and not as SSS 9. At the same time, the majority of studies do not clarify this point, and include among SSS subjects who have associated factors such as sinusitis, chronic nasal congestion and other sinonasal symptoms of obstruction, even though these are not considered diagnostic criteria (Tab. II).

Finally, 7 studies did not specify diagnostic criteria, which were extrapolated from the clinical description of cases. This risks producing inaccurate studies given that the literature lacks in consensus in SSS diagnosis and the reader may find its definition confusing.

From our analysis, it appears that the leading definition of SSS should include the evidence of enophthalmos and maxillary atelectasia. We believe that presence of sinonasal diseases and history of facial trauma may be reasonable factors to be included in anamnestic data because of the comparable clinical presentation and treatment.


Our proposal for definition is:

  1. criteria to diagnose SSS are contemporary presence of enophtalmos and maxillary atelectasia;
  2. minor associated factors may be the presence of sinonasal diseases and history of facial trauma.


Most studies only required CT for imaging investigation, since the relevance was to investigate maxillary bony walls atelectasia with possible resorption of the orbital floor. Nevertheless, 7 groups also considered it useful to add MR scans (Tab. I) to evaluate:

  1. dislocation of extra and intra-conical fat, extrinsic ocular muscles and optic nerve;
  2. differentiation between mixed signal central secretions and high signal peripheral;
  3. thick edematous mucosal lining within the maxillary sinus 6,18,23.


Only CT scan is required. MR imaging can be associated in selected cases, and specifically to evaluate a marked hypoglobus. We propose to add evaluation of extraocular muscle movement and potential diplopia at first ENT clinical evaluation, in order to select symptomatic and therefore the most critical cases 10,20.


The review also showed disagreement on management strategies. Seventeen authors proposed combined FESS and OR surgery as the leading therapy to obtain resolution of anatomical impairment and diplopia, if present. Among these, the majority (n = 9) performed both the procedures simultaneously, while 4 preferred to first carry out FESS surgery and to observe a possible progressive improvement of the enophtalmos to decide whether or not to perform additional OR. Eventually, 3 studies performed FESS and either simultaneous or delayed OR according to the criticality of the case (Tab. III).

The reasons which guide each surgical team towards one choice or another are multiple. The main factor is undoubtedly the severity of enophthalmos and hypoglobus, although no study defined a quantitative cut-off which could help in the surgical decision. OR approach is supported by the fact that, although there have been reports of resolution of the progression of enophthalmos by antrostomy alone, it is unclear whether other aesthetic deformities caused by SSS as hypoglobus or superior sulcus deformity also respond. Behbehani et al. believe that delaying orbital implant placement in cases with significant enophthalmos and hypoglobus is unjustified since complications like diplopia or infection are rare with this procedure. Furthermore, simultaneous implant placement also obviates the need for additional anaesthesia and hospitalisation 25. Cobb et al. maintain that FESS alone may stop the descent of the orbital wall, but there would be no reason to expect that the position of the orbital floor, and thus the globe, would be reversed 21.

On the contrary, Thomas et al. support delayed repair of the orbital floor as in some patients enophthalmos improves with antrostomy alone 22. Moreover, OR has not been shown to provide any significant restoration in the orbital muscle functions, and because of that diplopia is not corrected 6.

A total of 116 patients underwent FESS surgery alone, being considered as a necessary and sufficient procedure to resolve MA and enophthalmos (Tab. III). If we consider the entire case series of the review, FESS alone appears as the leading therapeutic choice, with only 7 reporting residual enophthalmos (6%), and 4 requiring subsequent OR (3.4%). Moreover, Numa et al. undertook a review of 84 cases and concluded that for patients with SSS diagnosis, uncinectomy alone may be sufficient 24.

FESS + OR follows with 72 cases treated with this management. Wait & see (57 patients) may be a valid alternative in asymptomatic cases or young population 13. OR alone (8 patients) and antibiotic therapy (1 patient) remain marginal therapeutic options (Tab. III).

This leads us to the conclusion that most of SSS may be successfully treated with isolated FESS surgery, sparing OR as a rescue procedure in case of non-satisfactory resolution of enophthalmos or diplopia.


FESS is the leading treatment for SSS and orbital reconstruction should be performed only in selected and symptomatic cases or, if needed, in a second approach when no resolution is seen. The proposed timepoint for a potential postponed OR, according to the literature, is 6 months.

Our review clearly shows the need to develop consensus regarding the definition of SSS and most of all its management. Even if the literature has started to find marginal consensus in recent years, it appears necessary to define shared diagnostic criteria, as well as a shared approach to the best treatment choices with the lowest rate of invasiveness and morbidity. The literature would also benefit from prospective studies on the best outcome in SSS management.


Literature about SSS is controversial and confusing. Our systematic review illustrates that the leading definition of SSS includes the evidence of enophthalmos and maxillary atelectasia by CT. Hypoglobus, presence of sinonasal diseases and history of facial trauma may or may not be associated, although the clinical relevance and management seems to be comparable. FESS alone appears to be the first choice of treatment, since at post-operative follow-up, orbital floor retraction tends to spontaneously reverse with clinically satisfactory results.


We gratefully thank the Librarians from the Università degli Studi di Milano, Biblioteca del Polo Centrale. Without their help, we would not have been able to locate and analyse a significant number of the studies included in this systematic review.

Conflict of interest statement

The authors declare no conflict of interest.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author contributions

CR made a substatial contribution to the conception and design of the article, to the acquisition, analysis and interpretation of data. AMS and GF critically revised the article and gave the final approval of the version to be published. GP made a substatial contribution to the conception and design of the article and gave the final approval of the version to be published.

Figures and tables

Figure 1.PRISMA flow-chart.

Study (year) Study design Sample size Mean age (range) in years Diagnostic criteria Associated factors Diagnosis Surgical approach Surgical timeline Outcome Complications Follow-up (months)
Behbehani 25 (2006) 5 36.7 (32-42) En Post-traumatic (1) CT scans FESS and OR (5) One step (5) 100% CI or CR Residual 1mm En (2) 24
RCS Hypoglobus Chronic sinusitis (4) Transient infraorbital hypoaesthesia (1)
Bossolesi 18 (2008) Case reports 4 42 (38-45) En Chronic sinusitis (2) End FESS and OR (4) One step (4) 100% CR None 12-24
Opacified maxillary sinus CT
Absence of major sinus pathology MR
Absence of previous trauma, surgery or congenital facial deformity
Brown 16 (2017) RCS and review 6 43 (35-52) En Chronic sinusitis (1) CT FESS (1) One step (1) 100% CI Residual 2 mm En (1) Not defined
MA Post-traumatic (6) OR (1) Two steps (3) minor diplopia (1)
Hypoglobus FESS and OR (4)
Chariba 11 (2014) RCS 13 34 (13-61) En Chronic sinusitis (5) CT FESS (13) N/A 100% CI Orbital breach (2) 30
Chavez-Montoya 26 (2017) RCS 3 44 (37-48) MA Nasal polyposis (1) CT FESS (1) One step (1) 100% CI - 24
Opacified maxillary sinus FESS and OR (1)
Wait & see (1)
Claròs 12 (2015) Case reports 3 36.3 (25-45) Not defined - CT FESS + OR (3) One step (3) 100% CR None Not defined
Low pressure in maxillary sinus
Claròs 10 (2019) RCS 13 38 (25-53) Not defined - CT FESS + OR (13) One step (13) 100% CI None Not defined
Orbital floor resorption
Absence of trauma and congenital facial deformity
Cobb 21 (2012) Case reports 3 44 (30-60) En Post-traumatic (2) CT FESS and OR (3) One step (2) 100% CI None 12(1) 36(1) 48(1)
MA Post-surgical (1) MR Two steps (1)
Maxillary opacity
De Dorlodot 7 (2017) RCS 4 44 (12-60) Facial asymmetry - CT FESS (3) Two steps (1) 100% CI Slight enophtalmos in some patients (No. not defined) Not defined
En and/or hypoglobus FESS and OR (1)
Absence of sinonasal symptoms
Eyigor 6 (2016) RCS 16 42.37 (20-66) MA - CT FESS (16) N/A Ongoing follow-up Ongoing follow-up Ongoing
Absence of trauma or sinusitis
Farneti 3 (2017) RCS and review 6 10 (7-14) Absence of sinusitis - CT FESS (6) N/A 100% CR Residual headache (1) 18-135
Remodeling of orbital floor at CT/MR scans
Opacified maxillary sinus
Absence of trauma or congenital deformities
Freiser 13 (2020) RCS 57 12.5 (3.7-18) Not defined - CT FESS (19) N/A 100% CI or CR Not defined Not defined
En Wait & see (38)
Gaudino 23 (2013) RCS 6 44 (22-67) En - CT FESS (1) One step (1) 2 FESS: no significant CI Not defined Not defined
Diplopia MR FESS and OR (2) Two steps (1) 2 FESS and OR: CI
Opacified sinus Wait & see (3)
Illner 27 (2002) RCS 5 47 (39-65) Not defined - CT/MR FESS (3) N/A Not defined Not defined Not defined
En Antibiotic therapy (1)
Hypoglobus Wait & see (1)
Maxillary sinus completely developed
Maxillary sinus opacified
Infundibulum occluded
Kashima 28 (2016) RCS 11 39.5 (23-62) Not defined Not defined Not defined FESS and OR (11) One step (11) 100% CI Residual enophthalmos (1) 9
MA 1 mm over correction (1)
En Lower eye-lid retraction (1)
Hypolgobus Nasolacrimal duct obstruction (1)
Kohn 29 (2013) RCS 22 41.2 (22-70) En Chronic rhinosinusitis (9) CT/MR Not defined Not defined Not defined Not defined Not defined
Hypoglobus Post-traumatic (10)
Orbital changes at CT scans
Korn 17 (2009) Case reports 5 Not defined MA Chronic rhinosinusitis (2) CT FESS and OR (5) One step (5) 100% CI Transient infraorbital Hypoaesthesia (1) Not defined
Orbital floor resorption Residual diplopia (1)
Lee 30 (2018) Case reports 3 44.6 (37-55) En Post-traumatic (1) CT FESS (1) N/A 100% CI Residual diplopia (1) Not defined
Hypoglobus MR OR (1) Residual enophthalmos (1)
MA Wait & see (1)
Opacified maxillary sinus
Lin 31 (2015) RCS 9 Not defined MA Post-traumatic (1) CT FESS (7) Two steps (2) 2 FESS alone did not resolved enophthalmos and so underwent OR None 21.4
Orbital floor resorption FESS and OR (2)
Absence of sinusitis
Martìnez-Capoccioni 32 (2016) RCS 20 44.2 (28-67) En and/or Hypoglobus Nasal obstruction (9) CT FESS (15) N/A 100% CI None 6-18
Endoscopic findings of MA Wait & see (5)
Altered facial appearance
Maxillary contraction and orbital enlargement at CT scans
Rose 33 (2003) RCS 14 41.3 (25-78) Not defined - CT OR (6) N/A 100% CI None 5-33
En Wait & see (8)
Remodeling of orbital floor
Absence of nasal diseases
Sesenna 34 (2010) Case reports 3 39 (28-46) En - CT FESS and OR (3) One step (2) 100% CR None 10-16
Absence of sinusitis, trauma and congenital deformities
Orbital floor remodeling at CT scans
Sivasubramaniam 35 (2011) RCS 18 Not defined (19-54) En and/or Hypoglobus - CT FESS (18) N/A 78% CR Residual enophthalmos (1) 15-120
MA 17% CI
Altered facial appearance
Absence of sinusitis
Thomas 22 (2003) RCS 4 32 (27-35) En - CT FESS and OR (2) Two steps (2) 100% CR Residual enophthalmos after FESS alone (2) which required second step surgery with OR Not defined
Absence of sinusitis FESS (2)
Opacified maxillary sinus
Inferior bowing of orbital floor
Vander Meer 4 (2001) RCS 4 42 (38-47) En - CT FESS and OR (4) One step (4) 100% CR none 2-36
Absence of sinusitis, trauma or congenital deformities
Remodeling of orbital floor at CT scans
Virgin 36 (2008) RCS 5 42 (22-65) En - CT FESS (4) Two steps (1) 100% CR None 24
MA FESS and OR (1)
Wan 37 (2000) Case reports 3 41 (38-44) Not defined Chronic sinusitis (1) CT FESS (3) N/A 100% CR none N/A
Remodeling orbital floor
Wise 19 (2007) RCS 11 46.5 (11-70) En - CT FESS (3) Not defined Not defined none Not defined
Focused only on CT findings Opacified maxillary sinus FESS and OR (8)
Orbital floor remodelling
Absence of chronic sinusitis, trauma or congenital deformities
Table I.Baseline data of studies included.
Not directly defined Study (year) En Hypoglobus MA Opacified maxillary Sinus No previous trauma, surgery or congenital deformities No sinonasal symptoms Post-traumatic Facial asymmetry Diplopia Orbital floor remodeling at CT
Behbehani 25 (2006) X X X
Bossolesi 18 (2008) X X X X
Brown 16 (2017) X X X X
Chariba 11 (2014) X X
Chavez-Montoya 26 (2017) X X
x Claròs 12 (2015) X X X
x Claròs 10 (2019) X X X X
Cobb 21 (2012) X X X
De Dorlodot 7 (2017) X X X X X
Eyigor 6 (2016) X X X
Farneti 3 (2017) X X X X
x Freiser 13 (2020) X X X
Gaudino 23 (2013) X X X X
x Illner 27 (2002) X X X
x Kashima 28 (2016) X X X
Kohn 29 (2013) X X X X
Korn 17 (2009) X X
Lee 30 (2018) X X X X
Lin 31 (2015) X X X X X
Martìnez-Capoccioni 32 (2016) X X X X X
x Rose 33 (2003) X X X X
Sesenna 34 (2010) X X X X X X
Sivasubramaniam 35 (2011) X X X X X
Thomas 22 (2003) X X X X X
Vander Meer 4 (2001) X X X X X
Virgin 36 (2008)
Wan 37 (2000) X X
x Wise 19 (2007) X X X X
7 TOTAL 24 15 23 7 6 9 3 3 1 10
Table II.Summary of diagnostic criteria for SSS.
Study (year) FESS + OR FESS OR Wait & see Antibiotic therapy
Behbehani 23 (2006) X (5)
Bossolesi 16 (2008) X (4)
Brown 14 (2017) X (4) X (1) X (1)
Chariba 11 (2014) X (13)
Chavez-Montoya 24 (2016) X (1) X (1) X (1)
Claròs 12 (2015) X (3)
Claròs 10 (2019) X (13)
Cobb 19 (2012) X (3)
De Dorlodot 7 (2017) X (1) X (3)
Eyigor 6 (2016) X (16)
Farneti 3 (2017) X (6)
Freiser 13 (2020) X (19) X (38)
Gaudino 21 (2012) X (2) X (1) X (3)
Illner 25 (2002) X (3) X (1) X (1)
Kashima 26 (2016) X (11)
Kohn 27 (2013) - - - - -
Korn 17 (2009) X (5)
Lee 28 (2019) X (1) X (1) X (1)
Lin 29 (2015) X (2) X (7)
Martìnez-Capoccioni 30 (2016) X (15) X (5)
Rose 31 (2003) X (6) X (8)
Sesenna 32 (2010) X (3)
Sivasubramaniam 33 (2011) X (18)
Thomas 20 (2002) X (2) X (2)
Vander Meer 4 (2001) X (4)
Virgin 34 (2008) X (1) X (4)
Wan 35 (2000) X (3)
Wise 17 (2007) X (8) X (3)
TOTAL 17 17 3 7 1
TOTAL PER CASES 72 116 8 57 1
Table III.Summary of therapeutic strategies for SSS.


  1. Blackwell KE, Calcaterra TC, Goldberg RA. Atelectasis of the maxillary sinus with enophthalmos and midface depression. Ann Otol Rhinol Laryngol. 1993; 102:429-432. DOI
  2. Soparkar CNS, Patrinely JR, Cuaycong MJ. The silent sinus syndrome: a cause of spontaneous enophthalmos. Ophthalmology. 1994; 101:772-778. DOI
  3. Farneti P, Sciarretta V, Macrì G. Silent sinus syndrome and maxillary sinus atelectasis in children. Int J Pediatr Otorhinolaryngol. 2017; 98:150-157. DOI
  4. Vander Meer JB, Harris G, Toohill RJ. The silent sinus syndrome: a case series and literature review. Laryngoscope. 2001; 111:975-978. DOI
  5. Hens G, Hermans R, Jorissen M. Chronic maxillary atelectasis. B ENT. 2005; 1:25-29.
  6. Eyigör H, Çekiç B, Çoban DT. Is there a correlation between the clinical findings and the radiological findings in chronic maxillary sinus atelectasis?. J Cranio-Maxillofacial Surg. 2016; 44:820-826. DOI
  7. De Dorlodot C, Collet S, Rombaux P. Chronic maxillary atelectasis and silent sinus syndrome: two faces of the same clinical entity. Eur Arch Otorhinolaryngol. 2017; 274:3367-3373. DOI
  8. Ende K, Mah L, Kass ES. Progression of late-stage chronic maxillary atelectasis. Ann Otol Rhinol Laryngol. 2002; 111:759-762. DOI
  9. Brandt MG, Wright ED. The silent sinus syndrome is a form of chronic maxillary atelectasis: a systematic review of all reported cases. Am J Rhinol. 2008; 22:68-73. DOI
  10. Clarós P, Sobolewska AZ, Cardesa A. Silent sinus syndrome: combined sinus surgery and orbital reconstruction-report of 15 cases. Acta Otolaryngol. 2019; 139:64-69. DOI
  11. Chariba I, Lazard DS, Sain-Oulhen C. Correlation between the rate of asymmetry volume of maxillary sinuses and clinical symptomatology in the silent sinus syndrome: a retrospective study about 13 cases. Rev Laryngol Otol Rhinol. 2014; 135:197-200.
  12. Clarós P, Ahmed H, Minka Ngom EG. Le silent sinus syndrome: reconstruction orbitaire par implant Medpor [The silent sinus syndrome: A reconstruction of the orbital floor with Medpor implant]. Rev Laryngol Otol Rhinol. 2015; 136:37-40. PubMed
  13. Freiser ME, McCoy J, Shaffer AD. Silent sinus syndrome in children. Int J Pediatr Otorhinolaryngol. 2020; 134:110034. DOI
  14. Moher D, Liberati A, Tetzlaff J, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009; 62:1006-1012. DOI
  15. Amir-Behghadami M, Janati A. Population, Intervention, Comparison, Outcomes and Study (PICOS) design as a framework to formulate eligibility criteria in systematic reviews. Emerg Med J. 2020; 37:387. DOI
  16. Brown SJ, Hardy TG, McNab AA. ‘Silent Sinus Syndrome’ following orbital trauma: a case series and review of the literature. Ophthal Plast Reconstr Surg. 2017; 33:209-212. DOI
  17. Korn BS, Weisman RA, Kikkawa DO. Multidisciplinary approach to management of silent sinus syndrome. Laryngoscope. 2009; 119:S180. DOI
  18. Bossolesi P, Autelitano L, Brusati R. The silent sinus syndrome: diagnosis and surgical treatment. Rhinology. 2008; 46:308-316.
  19. Wise SK, Wojno TH, DelGaudio J. M. Silent sinus syndrome: lack of orbital findings in early presentation. Am J Rhinol. 2007; 21:489-494. DOI
  20. Brown SJ, McNab AA. Ethmoid silent sinus syndrome following orbital trauma. Ophthal Plast Reconstr Surg. 2017; 33:e60-e61. DOI
  21. Cobb AR, Murthy R, Cousin G. Silent sinus syndrome. Br J Oral Maxillofac Surg. 2012; 50:e81-e85. DOI
  22. Thomas RD, Graham SM, Carter KD. Management of the orbital floor in silent sinus syndrome. Am J Rhinol. 2003; 17:97-100.
  23. Gaudino S, Di Lella GM, Piluddu E. CT and MRI diagnosis of silent sinus syndrome. Radiol Med. 2013; 118:265-275. DOI
  24. Numa WA, Desai U, Gold DR. Silent sinus syndrome: a case presentation and comprehensive review of all 84 reported cases. Ann Otol Rhinol Laryngol. 2005; 114:688-694. DOI
  25. Behbehani R, Vacareza N, Bilyk JR. Simultaneous endoscopic antrostomy and orbital reconstruction in silent sinus syndrome. Orbit. 2006; 25:97-101. DOI
  26. Chavez-Montoya R, Araujo-Ramírez O, Castillo-López IY. Imploding antrum syndrome: three cases with different management approaches. Cir y Cir (English Ed.). 2017; 85:529-534. DOI
  27. Illner A, Davidson HC, Harnsberger HR. The silent sinus syndrome: clinical and radiographic findings. Am J Roentgenol. 2002; 178:503-506. DOI
  28. Kashima T, Goldberg RA, Kohn JC. One-stage bone strip reconstruction technique with balloon sinus dilatation surgery for chronic maxillary atelectasis. Clin Ophthalmol. 2016; 10:2363-2368. DOI
  29. Kohn JC, Rootman DB, Xu D. Infratemporal fossa fat enlargement in chronic maxillary atelectasis. Br J Ophthalmol. 2013; 97:1005-1009. DOI
  30. Lee DS, Murr AH, Kersten RC. Silent sinus syndrome without opacification of ipsilateral maxillary sinus. Laryngoscope. 2018; 128:2004-2007. DOI
  31. Lin GC, Sedaghat AR, Bleier BS. Volumetric analysis of chronic maxillary atelectasis. Am J Rhinol Allergy. 2015; 29:166-169. DOI
  32. Martínez-Capoccioni G, Varela-Martínez E, Martín-Martín C. Silent sinus syndrome an acquired condition and the essential role of otorhinolaryngologist consultation: a retrospective study. Eur Arch Otorhinolaryngol. 2016; 273:3183-3188. DOI
  33. Rose GE, Lund VJ. Clinical features and treatment of late enophthalmos after orbital decompression: a condition suggesting cause for idiopathic ‘imploding antrum’ (silent sinus) syndrome. Ophthalmology. 2003; 110:819-826. DOI
  34. Sesenna E, Oretti G, Anghinoni ML. Simultaneous management of the enophthalmos and sinus pathology in silent sinus syndrome: a report of three cases. J Craniomaxillofac Surg. 2010; 38:469-472. DOI
  35. Sivasubramaniam R, Sacks R, Thornton M. Silent sinus syndrome: dynamic changes in the position of the orbital floor after restoration of normal sinus pressure. J Laryngol Otol. 2011; 125:1239-1243. DOI
  36. Virgin F, Ling FTK, Kountakis SE. Radiology and endoscopic findings of silent maxillary sinus atelectasis and enophthalmos. Am J Otolaryngol. 2008; 29:167-170. DOI
  37. Wan MK, Francis IC, Carter PR. Spectrum of presentation of Silent Sinus Syndrome. J Neuroophthalmol. 2000; 20:207-212. DOI


Cecilia Rosso

Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, Milan, Italy

Alberto Maria Saibene

Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, Milan, Italy

Giovanni Felisati

Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy

Carlotta Pipolo

Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy


© Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale , 2022

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