Head and neck
Published: 2022-04-08
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Development of a prognostic model of overall survival in oropharyngeal cancer from real-world data: PRO.M.E.THE.O.

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
https://orcid.org/0000-0001-9666-3033
Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
https://orcid.org/0000-0002-7722-290X
Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
https://orcid.org/0000-0003-0383-6412
Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
https://orcid.org/0000-0002-8061-6977
Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
https://orcid.org/0000-0002-7740-747X
Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
https://orcid.org/0000-0002-8366-1474
Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Itay;
https://orcid.org/0000-0001-8999-5208
Department of Radiation Oncology, Azienda-Ospedaliero-Universitaria Careggi, University of Florence, Italy
https://orcid.org/0000-0002-9880-8387
Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Health Science (DISSAL), University of Genoa, Genoa, Italy
https://orcid.org/0000-0003-0508-6344
Department of Health Science (DISSAL), University of Genoa, Genoa, Italy
https://orcid.org/0000-0001-6875-5803
Radiation Oncology, University Hospital of Modena, Italy
https://orcid.org/0000-0002-5954-0939
Medical Oncology, University Hospital of Modena, Italy
https://orcid.org/0000-0002-8112-2936
Department of Radiation Oncology, S. Croce and Carle Teaching Hospital, Cuneo, Italy
https://orcid.org/0000-0002-6412-6660
Department of Oncology, S. Croce and Carle Teaching Hospital, Cuneo, Italy
https://orcid.org/0000-0002-8605-4290
Department of Oncology, Radiation Oncology, University of Turin, Turin, Italy
https://orcid.org/0000-0003-2276-0687
Otolaryngology Division, Sassari University Hospital, Sassari, Italy
https://orcid.org/0000-0001-6261-2772
Dipartimento Scienze dell’Invecchiamento, Neurologiche, Ortopediche e della Testa-collo, UOC di Otorinolaringoiatria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore, Roma, Italy
https://orcid.org/0000-0003-2480-1243
Department of Oncology, Radiation Oncology, University of Turin, Turin, Italy
https://orcid.org/0000-0003-4406-7621
Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore, Roma, Italy
https://orcid.org/0000-0003-4637-6487
prediction model personalized medicine cetuximab head and neck tumour

Abstract

Objective. The PRO.M.E.THE.O. study (PredictiOn Models in Ent cancer for anti-EGFR based THErapy Optimization) aimed to develop a predictive model (PM) of overall survival (OS) for patients with locally advanced oropharyngeal cancer (LAOC) treated with radiotherapy (RT) and cetuximab (Cet) from an Italian dataset.
Methods. We enrolled patients with LAOC from 6 centres treated with RT-Cet. Clinical and treatment variables were collected. Patients were randomly divided into training (TS) (80%) and validation (VS) (20%) sets. A binary logistic regression model was used on the TS with stepwise feature selection and then on VS. Timepoints of 2, 3 and 5 years were considered. The area under the curve (AUC) of receiver operating characteristic of 2, 3 and 5 year and confusion matrix statistics at 5-threshold were used as performance criteria.
Results. Overall, 218 patients were enrolled and 174 (79.8%) were analysed. Age at diagnosis, gender, ECOG performance, clinical stage, dose to high-risk volume, overall treatment time and day of RT interruption were considered in the final PMs. The PMs were developed and represented by nomograms with AUC of 0.75, 0.73 and 0.73 for TS and 0.713, 0.713, 0.775 for VS at 2, 3 and 5 years, respectively.
Conclusions. PRO.M.E.THE.O. allows the creation of a PM for OS in patients with LAOC treated with RT-Cet.

Affiliations

Francesco Miccichè

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

Giuditta Chiloiro

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

Silvia Longo

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

Rosa Autorino

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

Mariangela Massaccesi

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

Jacopo Lenkowicz

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

Pierluigi Bonomo

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Itay;

Isacco Desideri

Department of Radiation Oncology, Azienda-Ospedaliero-Universitaria Careggi, University of Florence, Italy

Liliana Belgioia

Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Health Science (DISSAL), University of Genoa, Genoa, Italy

Almalina Bacigalupo

Department of Health Science (DISSAL), University of Genoa, Genoa, Italy

Elisa D'Angelo

Radiation Oncology, University Hospital of Modena, Italy

Federica Bertolini

Medical Oncology, University Hospital of Modena, Italy

Anna Merlotti

Department of Radiation Oncology, S. Croce and Carle Teaching Hospital, Cuneo, Italy

Nerina Denaro

Department of Oncology, S. Croce and Carle Teaching Hospital, Cuneo, Italy

Pierfrancesco Franco

Department of Oncology, Radiation Oncology, University of Turin, Turin, Italy

Francesco Bussu

Otolaryngology Division, Sassari University Hospital, Sassari, Italy

Gaetano Paludetti

Dipartimento Scienze dell’Invecchiamento, Neurologiche, Ortopediche e della Testa-collo, UOC di Otorinolaringoiatria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore, Roma, Italy

Umberto Ricardi

Department of Oncology, Radiation Oncology, University of Turin, Turin, Italy

Vincenzo Valentini

Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore, Roma, Italy

Copyright

© Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale , 2022

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