Otology
Published: 2024-02-29
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Effect of stapes demineralisation on the development of cochlear otosclerosis

Department of Otolaryngology, Jagiellonian University Medical College, Kraków, Poland
https://orcid.org/0000-0003-0840-9268
Department of Otolaryngology, Head and Neck Surgery, Medical University, Warsaw, Poland
https://orcid.org/0000-0002-7758-4740
Department of Otolaryngology, Head and Neck Surgery, Medical University, Warsaw, Poland
https://orcid.org/0000-0003-3013-6403
Department of Otolaryngology, Jagiellonian University Medical College, Kraków, Poland
https://orcid.org/0000-0002-1793-0744
otosclerotic lesions cochlear otosclerosis stapes demineralisation scanning electron microscope stapes microstructure

Abstract

Objective. The involvement of the inner ear in otosclerosis may lead to the development of cochlear otosclerosis. The aim of this study was to analyse changes in the chemical composition and microstructure of the stapes in the course of otosclerosis compared to healthy stapes.
Materials and methods. This analysis included 31 patients with otosclerosis and 9 patients without otosclerosis. Microanalytical and diffraction techniques were used to assess the elemental distribution and orientation topography of the stapes.
Results. The concentration of Ca2+ in the study group was significantly lower in the area of the anterior crus of the stapes than in the posterior crus. A reduction in the Ca2+/P3+ ratio in the anterior crus was associated with deteriorated bone conduction and tinnitus. Degradation of the stapes microstructure in the area of otosclerotic lesions was observed with scanning electron microscopy.
Conclusions. Bone remodelling is most significant at the closest location to typical otosclerotic lesions with hydroxyapatite porosity and scale-like bone formation according to scanning electron microscopy. There is a relationship between the disturbance of calcium metabolism and the development of clinical symptoms of cochlear otosclerosis.

Affiliations

Maciej Wiatr

Department of Otolaryngology, Jagiellonian University Medical College, Kraków, Poland

Robert Bartoszewicz

Department of Otolaryngology, Head and Neck Surgery, Medical University, Warsaw, Poland

Kazimierz Niemczyk

Department of Otolaryngology, Head and Neck Surgery, Medical University, Warsaw, Poland

Agnieszka Wiatr

Department of Otolaryngology, Jagiellonian University Medical College, Kraków, Poland

Copyright

© Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale , 2024

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