Published: 2018-02-01

Anterior palatoplasty in the treatment of obstructive sleep apnoea - a systemic review

Consultant, Otolaryngology, Asia Sleep Centre, Paragon, Singapore
Student, Otolaryngology, Asia Sleep Centre, Paragon, Singapore
Student, Otolaryngology, Asia Sleep Centre, Paragon, Singapore
Consultant, Otolaryngology Head and Neck Surgery Western University, London Ontario, Canada
Anterior palatoplasty Obstructive sleep apnoea Systemic review Level of Evidence: 2a


This study seeks to determine the objective and subjective success rates of anterior palatoplasty and its variants for the treatment of obstructive
sleep apnoea (OSA). A systematic review with two independent searches of Medline, PubMed, Cochrane Library and Evidence Based
Medicine Reviews was performed to identify publications relevant to OSA and anterior palatoplasty. All relevant studies published before
30 June 2015 were included. Six studies were included in the systematic review. The numbers of patients in each paper ranged from 13 to
77 (total = 240), and mean age ranged from 21 to 51 years. Substantial and consistent improvement in polysomnography (PSG) outcomes
were observed in patients after the anterior palatoplasty, with or without multilevel surgery. The results showed that the anterior palatoplasty
technique provides significantly improvement in the post-operative Apnoea-Hypopnea Index. The mean pre-operative AHI (in the 6 papers)
improved from 16.3 to 7.1, the snore visual analogue scale improved from 7.5 to 3.1 and the Epworth score reduced from 11.3 to 7.3
post-operatively. The overall pro-rated pooled success rate for all the patients was 72.5%, with a mean follow-up of 17.3 months. Anterior
palatoplasty is an effective option in the management of patients with mild to moderate OSA.


Snoring is considered a social nuisance and an objectionable social problem. It is caused by the vibration of the structures in the oral cavity and oropharynx – namely the soft palate, uvula, tonsils, base of tongue, epiglottis and pharyngeal walls. Many sleep authorities believe that it may represent an alarm to alert one to the possibility of obstructive sleep apnoea (OSA). OSA is a common sleep disorder; Young et al. studied 602 state employees with attended overnight polysomnography and found that the incidence of sleep disordered breathing (SDB) was 24% in men and 9% in women 1. Most of these patients are undiagnosed. It is estimated that up to 93% of females and 82% of males with moderate to severe OSA remain undiagnosed2. OSA is due to the collapsibility of the upper airway during sleep. These collapsible soft tissues, when subjected to negative pressure within the upper airway, may lead to complete or partial obstruction of the upper airway leading to cessation of breathing, increased sympathetic activity, increased blood pressure and hypoxaemia. Collapse of the upper airway is often multilevel, at the level of the palate/velopharynx, the base of tongue and/or the lateral pharyngeal walls. Patients with OSA have either a thick redundant soft palate and/or bulky lateral pharyngeal walls that contribute to the collapse and obstruction of the upper airway in these patients. These areas of collapse should be addressed, if one is aiming to relieve the patient of the apnoeas.

Many techniques that have been introduced to treat snoring and OSA, mainly aimed to create scar tissue, in order to incite fibrosis and stiffen the palate. With the stiffened palate, the vibration of the palate diminishes, and hence snoring is reduced. An anterior palatal stiffening operation was first introduced by Ellis in 1994 3 (this involved stripping of a small area of uvular and palatal mucosa) and modified by Mair in 2000 4. Both techniques had promising results, although they produced a stellate and puckered scar on the soft palate that resulted in tenting and pulling of the lateral pharyngeal walls medially, and therefore narrowing of the lateral distance between the tonsillar pillars laterally. These anatomic manifestations might explain why some patients did not experience much benefit from the procedure. Pang et al. described the modified cautery assisted palatal stiffening operation (CAPSO) technique done under local anaesthesia (LA) 5. This technique had showed encouraging results for patients with snoring and mild OSA 5. The modified CAPSO technique was renamed as the anterior palatoplasty in 2009, as the technique involved the anterior surface of the soft palate primarily 6.

We present a systemic review of anterior palatoplasty and its variants since its introduction 8 years ago.

Materials and methods

We performed a systematic literature search using Medline, Google Scholar, Cochrane Library and Evidence Based Reviews (up to June 30, 2015) databases for procedures that included anterior palatoplasty and its variants, mainly the modified CAPSO and the barbed anterior palatoplasty 7. The overall search strategy combined search terms of anterior palatoplasty, palate surgery, uvulopalatopharyngoplasty, sleep apnoea, obstructive sleep apnoea and outcomes.

Selection criteria

All relevant studies published prior to June 30, 2015 were included. All included studies had to be published in English and/or another language but with English translation. We included case control studies and/or cohort studies, with or without any form of comparison with the traditional treatment method for snoring and/or OSA. We included both adult and paediatric studies. The selection criteria for individual patients were based on patients with or without nasal obstruction, with mainly retro-palatal obstruction/narrowing and no hypo-pharyngeal collapse.

Data extraction

For studies that met inclusion criteria, data was extracted into a standardised worksheet. Extracted data included the name of the first author, year of publication, study design, number of study subjects in each treatment group, the age and gender of subjects, description of the surgical procedure, pre-operative and post-operative apnoea-hypopnea index (AHI) and success rates.

The primary effectiveness outcome measure was pre-operative and post-operative AHI values following the anterior palatoplasty with or without any comparison with the traditional uvulopalatopharyngoplasty and/or other surgical method like uvulopalatal flap (UVF). The secondary outcome was surgical success rate defined as a reduction of post-operative AHI by 50% (compared to pre-operative AHI) and an AHI value below 20. Means with standard deviations (SD) were summarised for the major outcome, and the AHI change before and after surgical intervention was evaluated as for the treatment effect. Other outcomes taken into consideration include, snoring visual analogue scale (VAS) reduction, Epworth sleepiness scale (ESS), snoring reduction (as a percentage), pain levels (as a VAS), pain duration (number of days) and two-year satisfaction (based on patient and bed partner reports).

Statistical methods

Data was analysed using a generic inverse method and p < 0.05 was regarded as statistically significant. Combined summary statistics of the standardised (STD) paired difference in mean for the individual studies are shown. Combined STD paired differences in means were calculated and a 2-sided p-value < 0.05 was considered to indicate statistical significance.

Procedural technique

Most of the papers had the anterior palatoplasty technique done under general anaesthesia, however, the anterior palatoplasty technique can be done under local anaesthesia in the office as well. General anaesthesia would be the standard choice if the patient had relatively larger sized tonsils (tonsil size 2, 3 or 4) and a tonsillectomy was needed.

The procedure may be done under local anaesthesia in the office as an out-patient. The patient was seated in an examination chair with the mouth open. Topical lidocaine (10%) was used to anaesthetise the palatal region. A total of 2 to 4 ml of 1:80,000 adrenaline and 2% xylocaine was injected into 3 sites of the soft palate. A partial uvulectomy (usually using diathermy/radiofrequency/coblation) may be performed, followed by supero-lateral cuts (para-uvular cuts) on either side of the uvula (especially if there were very prominent posterior and/or anterior palatal arch webbing), through both soft palatal arches. A horizontal rectangular strip of mucosa was removed from the soft palate (about 40 mm to 50 mm in length by 7 mm to 10 mm in width); down to the muscle layer. Haemostasis was achieved with electrocautery. The horizontal stripped area on the soft palate would be sutured with Vicryl 4/0 round body curved needle. A minimum of 10 to 20 sutures are used to appose the wound edges (while suturing, the entire soft palate would be transposed anteriorly and superiorly). All patients were prescribed anaesthetic gargles (Difflam) and lozenges (Difflam), non-steroidal anti-inflammatory agents (Naproxen Sodium), narcotics (e.g. codeine) and/or cyclo-oxygenase-2 inhibitors.

The same procedure may be carried out under general anaesthesia with the patient supine using the Boyle-Davies mouth gag with an oral intubation. Tonsillectomy was first performed followed by anterior palatoplasty (in the same fashion as described above). The anterior and posterior tonsillar pillars may or may not be sutured together, depending on the author/surgeon’s preference.

Barbed anterior palatoplasty is a variant or evolved technique of the anterior palatoplasty 7. The technique is similar to the anterior palatoplasty, and the barbed thread would be the addition in order to allow the suture to suspend the different mucosa and muscular planes without the need to tie knots. The authors used the double needle QUILL® knotless tissue closure device, Angiotech Pharmaceutical Inc., Vancouver, Canada 7. After the standard anterior palatoplasty, the barbed suture is passed from the pterygoid hamulus, pterygo-mandibular raphe from both sides, and passed through the rectangle box superiorly and inferiorly in a zig-zag fashion. The authors conclude their description of the procedure by including the Roman Blind technique proposed by Mantovani et al. 8 9.


From the Medline and PubMed search, with the keywords “sleep apnoea” and “palatoplasty” search yielded 20 papers; after narrowing the search down to specific “anterior palatoplasty” in “sleep apnoea” only 10 papers were retreived, which had included palatopasty for cleft palates. The refined database search only identified six studies potentially eligible for review (specific to sleep apnoea and the anterior palatoplasty method) and analysis (Tables I, II) 5-7 10-12. Two studies had a comparison group with either the uvulopalatal flap 10 or the modified uvulopalatopharyngoplasty 11, this is illustrated separately in Table III. The other studies had reported the various result outcomes in terms of AHI, lowest oxygen desaturation, Epworth sleepiness scale, snore VAS, snoring reduction, and/or pain score and pain duration (Tables I, II). Five studies reported the ages, the mean body mass index (BMI) and pre/post-operative AHI; only 2 papers reported their pre/post-operative lowest oxygen values, while four papers reported their overall post-operative success rates, defined as a reduction of post-operative AHI by 50% (compared to pre-operative AHI) and an AHI value below 20 5-7 10-12.

The numbers of patients in each paper ranged from 13 to 77 (total = 206), and mean age range from 21 to 51 years. Mean BMI was 28.6. Substantial and consistent improvement in PSG outcomes were observed in patients after the anterior palatoplasty, with or without multilevel surgery. The results showed that the anterior palatoplasty technique is associated with significant improvement in post-operative AHI. The mean pre-operative AHI (in the 6 papers) improved from 16.3 to 7.1 postoperative, the lowest oxygen saturation improved from a mean of 84.5% to 92% (in the 2 papers that reported); the snore visual analogue scale (in the 5 papers) improved from 7.5 to 3.1, the Epworth score (in the 5 papers) reduced from 11.3 to 7.3, post-operatively (Tables I, II). One study by Marzetti et al. reported an overall snoring reduction of 80% in their 34 patient cohort.

The overall pro-rated pooled success rate for patients (in the 4 studies that reported, n = 132) was 72.5%, with a mean follow-up of 17.3 months (Table I).

Two of these six articles had included a comparison group, other than the anterior palatoplasty technique 10-11 (Table III). Marzetti et al. had compared the anterior palatoplasty technique with the traditional uvulopalatal flap technique 10. They found that the respective AHI and ESS had significant improvement in the anterior palatoplasty group compared to the uvulopalatal flap group (p < 0.05) (Table III). Of interest, Marzetti et al. reported that both pain intensity and duration was lower in the anterior palatoplasty compared to the uvulopalatal flap group. Ugur et al. also reported similar results with the anterior palatoplasty group showing greater improvements in both ESS and snoring reduction compared to the modified uvulopalatopharyngoplasty group 11(Table III). Ugur et al. also showed that the 2 year overall satisfaction rate was significantly higher in the anterior palatoplasty group than in the modified uvulopalatopharyngoplasty group (85% vs. 70%, respectively) 11 (Table III).


In 2000, Mair et al. 4 reported a promising 77% success rate for snoring reduction in 206 patients, at one year follow up, who underwent the cautery-assisted palatal stiffening operation (CAPSO). Pang et al. 5 modified the CAPSO technique and had showed encouraging results in a small group of patients with snoring and mild OSA. The modified CAPSO technique had combined the laser assisted uvulopalatoplasty (LAUP) 13 technique first described by Kamami and simple horizontal stripping of the soft palatal mucosa. Kamami et al. studied 417 snorers who underwent LAUP and found a reduction of snoring in 95% of patients after one year. Most authors report modest improvement after LAUP for patients with mild OSA 3 4 13. By combining the use of cautery with the principles of the laser palatoplasty and the creation of a horizontal denuded mucosal strip on the soft palate, with the suturing/closure of this horizontal strip, this technique is able to move the soft palate anteriorly and superiorly, while opening up the anterior-posterior velopharyngeal space. This technique opens up the retropalatal area by transposing the soft palate anteriorly; this is similar to advancing the entire palate forwards, as in Woodson’s transpalatal advancement pharyngoplasty 14 but without bone surgery, with less resulting morbidity and a lower risk of oro-nasal fistula.

The 3.year follow-up of 77 patients (38 snorers and 39 patients with OSA) reported by Pang et al. showed that AHI improved in patients with OSA, from 25.3 ± 12.6 to 11.0 ± 9.9 (p < 0.05) 6. The overall success rate (reduction of at least 50% of the pre-procedure AHI and post-procedure AHI below 20) for this OSA group was 71.8% (at mean 33.5 months, median follow-up at 31 months and a range of 29 to 39 months). The mean snore scores (VAS) improved from 8.4 to 2.5 (for all 77 patients) (p < 0.05) 6. Lowest oxygen saturation also improved in all OSA patients, from a mean pre-operative 81.4 ± 19.2 to 92.0 ± 16.9 (p < 0.05) 6. All patients had improvement in their snoring, and patients and their sleep partners were satisfied with the result at a mean of over 30 months postoperatively. The VAS showed gradual reduction in the snoring intensity with time, ranging from a preoperative level of 8.4 (range 7.5 to 9.1) to a low of 2.5 (range 1.0 to 4.6) at about 30 months postoperative 6. Similar improvements were seen in the Epworth scale which decreased from 16.2 (range 8 to 20) to 7.9 (range 5 to 13) postoperatively (p = 0.05) 6.

Marzetti et al. demonstrated the highest success rate in their 34 selected patients with mild to moderate OSA, with an impressive 86% success 10, while Ugur et al. produced only a 57.1% success rate in 42 patients with mild to moderate OSA after a 24 month follow-up 12. Salamanca et al. introduced the improved “barbed Roman blinds” technique with promising reductions in both AHI and snoring VAS, even if, unfortunately, they did not report on the success rate in their study of 46 patients 7.

Of great interest are the two papers comparing the anterior palatoplasty technique with the uvulopalatal flap (Marzetti et al. 10) and the modified uvulopalatopharyngoplasty (Ugur et al. 11). Both studies had shown improvements in both techniques compared, but greater impressive improvements in both AHI, ESS and snoring reduction VAS score were consistently demonstrated in the anterior palatoplasty group of patients.

It was also highlighted in 4 of the 6 papers reviewed herein that the overall pain intensity and duration post-operatively in the anterior palatoplasty technique was lower than with other traditional palatoplasty techniques 5 6,10 11.

These six investigations demonstrated subjective and objective improvements in the 240 patients studied; this may suggest that the palatal fibrotic scar achieved by this anterior palatoplasty technique is superior over other techniques described, and appears to be able to maintain the encouraging results in the long term. Pang et al. hypothesised a number of advantages of this procedure 6. It is anatomically sound (as it causes fibrotic scarring superiorly and anteriorly) and it can be done as an office-based procedure on an out-patient basis or part of a tonsillectomy (with or without preservation of the uvula) under general anaesthesia. The procedure is also fairly quick, low-cost and does not require expensive equipment.


This systematic review has shown that anterior palatoplasty has comparably favourable results in relation to other methods of palatal surgery in adults. The procedure is simple to perform, is anatomically sound and has minimal complications.

Figures and tables

N Age BMI AHI LSAT % Success F/U
Pre Post Pre Post
Pang 2007 5 13 35.7 28.4 12.3 5.2 88.3 92.5 75 3
Pang 2009 6 39 39.3 24.9 25.3 11.0 81.4 92.0 71.8 33.3
Marzetti 2013 10 38 > 20 26.7 22.0 8.6 86 2
Ugur 2013 11 50 43 28.8 24
Ugur 2014 12 42 39.2 35.3 13.2 7.3 57.1 24
Salamanca 2014 7 24 46 28.6 8.9 3.8
Overall 206 28.6 16.3 7.1 84.5 92.0 72.5 17.3
Table. I.Pre-operative and post-operative AHI, LSAT and success rates of the six papers included.
N Age BMI ESS Snore VAS Pain score Pain duration
Pre Post Pre Post
Pang 2007 5 13 35.7 28.4 12.2 8.9 8.3 3.3 Mild 10 days
Pang 2009 6 39 39.3 24.9 16.0 7.9 8.4 2.5 Mild 10 days
Marzetti 2013 10 38 > 20 26.7 8.5 4.9 80%↓ 5.1 7 days
Ugur 2013 11 50 43 28.8 8.4 6.5 5.3 3.4 6
Ugur 2014 12 42 39.2 35.3 11.5 8.3 6.2 3.4
Salamanca 2014 7 24 46 28.6 9.2 2.9 Mild-mod
Overall 206 28.6 11.3 7.3 7.5 3.1
Table. II.Illustrating the pre-operative and post-operative ESS, snore VAS and pain scores of the six papers included.
N Age BMI ESS AHI Snore VAS Success% F/U Pain VAS Pain (d) 2 yr satisfaction
Pre Post Pre Post Pre Post
Marzetti 2013 10 AP 15 48.3 26.5 8.5 4.9 22.0 8.6 80%↓ 86 2 5.1 7
UPF 19 46.3 26.6 8.1 5.2 23.0 9.6 70%↓ 84 2 6.8 10.8
Ugur 2013 11 AP 26 43.2 28.1 8.4 6.5 5.3 3.4 24 6.0 85%
ModUPPP 24 42.1 29.8 9.8 7.3 6.8 4.6 24 8.0 70%
Table. III.Demonstrating the comparative results between the Anterior Palatoplasty (AP) with the respective traditional techniques of the Uvulopalatal Flap (UPF) and the modified Uvulopalatopharyngoplasty (ModUPPP).


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Consultant, Otolaryngology, Asia Sleep Centre, Paragon, Singapore


Student, Otolaryngology, Asia Sleep Centre, Paragon, Singapore


Student, Otolaryngology, Asia Sleep Centre, Paragon, Singapore


Consultant, Otolaryngology Head and Neck Surgery Western University, London Ontario, Canada


© Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale , 2018

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