Published: 2019-05-21

The impact of intra-operative factors in otosclerosis outcomes: retrospective study in a tertiary centre

UOC Otorinolaringoiatria Universitaria, Azienda Ospedaliero-Universitaria Policlinico di Bari, Italy
UOC Otorinolaringoiatria Universitaria, Azienda Ospedaliero-Universitaria Policlinico di Bari, Italy
UOC Otorinolaringoiatria, Fondazione Policlinico A. Gemelli-IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy
UOC Otorinolaringoiatria, Fondazione Policlinico A. Gemelli-IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy
UOC Otorinolaringoiatria, Fondazione Policlinico A. Gemelli-IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy
Otosclerosis Stapedectomy Stapedotomy Hearing threshold


The aim of the study was to assess results from a large cohort of patients undergoing otosclerosis surgery with respect to the impact of intra-operative variables on post-operative hearing function and complications. We enrolled 384 patients affected by otosclerosis who were subjected to stapes surgery between 2004 and 2013 at a single institution. Surgery was performed in all cases under local anaesthesia, using a manual perforator and/or microdrill. Teflon-piston prosthesis was used in all patients. Audiological data obtained preoperatively and at last follow up examination (minimum 12 months) were compared. Statistical analysis was performed using the multiple regression model. Peripheral rim otosclerosis and diffuse otosclerosis were associated with better functional results compared to the obliterative pattern (p < 0.05). Mean postoperative Air-Bone Gap was significantly higher in the 0.4 mm, compared to 0.6 mm piston group at 0.5 kHz (p < 0.001) and 1 kHz (p < 0.02); in the stapedotomy group a statistically significant difference was found between 0.4 and 0.6 mm piston groups, in favour of the latter p < 0.05). No differences were encountered in terms of average hearing threshold and complications. Intra-operative variables cannot be fully predictable and our data could help in stratification of the results and as a landmark for the surgeon’s decisions.


Otosclerosis is a bone remodelling disorder involving the otic capsule, which leads to a fixation of the stapes footplate and to progressive hearing loss 1 2. In 1958 Shea 3 performed the first total stapedectomy and since then several technological advances have been introduced 4 5. Nowadays surgeons may choose among several techniques and materials and the identification of prognostic factors is crucial 6-8. Surgical technique (stapedotomy versus partial and total stapedectomy) and prosthesis characteristics have been evaluated as prognostic factors 9. Over the years several prostheses have been proposed in terms of size, material, fixation mechanism and shape. At the present time, reviews show conflicting results regarding the role of piston diameter: Wegner et al. 10 demonstrated that it does not represent a prognostic factor, whereas Laske et al. 11 reported better outcomes for a 0.6-mm piston.

Controversial results have been also reported regarding the surgical technique 12-15; recently, a meta-analysis on 21 studies 16 found no evidence for the superiority of laser versus conventional fenestration.

Besides surgical techniques, intrinsic characteristics of the pathology may influence the intra- and post-operative course. Gristwood 17 classified otosclerosis lesions into 9 types, although he ultimately compared “obliterated” versus “non-obliterated” patterns, demonstrating a better prognosis in the latter group. Portman’s classification 18 includes 5 types of otosclerosis characterised by progressive diffusion of the otosclerotic process, with type 1 corresponding to a small otosclerotic focus, localised at the fissula ante fenestram and type 5 corresponding to a complete obliteration of the footplate and oval window niche. The Portmann classification implies an increasing stapes fixation and surgical risk, based on the extension degree. Malafronte et al. 19 proposed a simpler classification of otosclerosis, based on the appearance of the stapes footplate: blue footplate, white footplate and obliterative footplate. Identification of colour variation before removal of the superstructure seems to be associated with the incidence of footplate complications. The latter classification refers to histologic patterns and thickness of the footplate (fragile/vitreous versus elastic/resistant).

The aim of the present study was to evaluate the effect of intra-operative variables on post-operative results and complications in a large cohort of patients affected by otosclerosis and operated on at our Department.

Materials and methods

From January 2004 to December 2013, 429 consecutive patients were subjected to stapes surgery at the Otolaryngology Unit, University of Bari. All surgical procedures were performed by one surgeon, namely the first author. The diagnosis of otosclerosis was based on normal otoscopic findings, a progressive conductive hearing loss as air conduction pure tone average > 30 dB in the range of 0.5 to 4 kHz and the absence of cochleostapedial reflexes. Tympanometry was not considered essential for diagnosis since it is almost universally normal or shows stiffness of the ossicular chain. Tympanometric data suggesting otitis media or tympanosclerosis led to exclusion of the surgical candidacy. Pre-operative CT scan was not considered as part of routine evaluation.

Subjects whose audiological reports before and/or after surgical treatment where not available and patients whose follow-up time was less than 12 months were excluded. Patients undergoing revision surgery, affected by tympanosclerosis, congenital anomalies, epitympanic fixation of the malleus or incus were also excluded. We enrolled 384 patients (248 females and 136 males) with a mean age of 47 years (range: 20-75 years) for data analysis. All patients had at least 12 months of post-operative follow-up. The study was approved by the Local Ethical Committee and was conducted in accordance with the ethical standards of the Declaration of Helsinki. Patients received adequate and comprehensible information about the surgical procedures and gave their written consent.

The following factors were evaluated: pre- and post-operative hearing threshold, surgical technique (partial stapedectomy, total stapedectomy, stapedotomy), diameter of the Teflon-piston (0.6 mm or 0.4 mm), intra- and post-operative complications (vertigo, facial palsy, tinnitus, sensorineural hearing loss) and type of otosclerosis pattern. Otosclerosis pattern was classified as: peripheral “well-delimited” rim fixation, diffuse and obliterative.

All patients were subjected to standard surgery under local anaesthesia using a transcanal approach as previously reported 12. The choice between partial stapedectomy (partial posterior platinectomy), or stapedotomy was only based on the amount of footplate that came out using the micro-hook. In case of obliterative otosclerosis a microdrill was used to perform a stapedotomy. According to the oval window niche anatomy and footplate opening dimensions, a 0.4 or 0.6 mm Teflon prosthesis was placed directly into the vestibule and the oval window niche was sealed with earlobe fat and blood.

Audiological evaluation was performed according to the guidelines of the American Academy of Otolaryngology Head and Neck Surgery 20: average thresholds were calculated at 500 Hz, 1 kHz, 2 kHz and 3 kHz. Last follow-up evaluation was performed on average at 30 months after surgery (range: 12-70 months).

Statistical analysis

Multiple linear regression analysis was performed. Mean post-operative air-bone gap (ABG), high frequency bone conduction (HFBC), calculated as the pre-operative minus the post-operative pure tone bone conduction average, obtained at least 6 weeks after surgery at 1, 2 and 4 kHz, bone conduction pure tone average (BCPTA) and pure tone average (PTA) were considered as the dependent variables, whereas independent variables were: type of otosclerosis, type of surgery, diameter of the piston, intra and post-operative complications. ANOVA and Chi-Square test were used to compare the groups. Statistical software (Statistica 8.0) was used for analysis and significance was set for p < 0.05.


The otosclerosis involved the peripheral rim in 186 patients (48%), and was diffuse in 172 patients (45%) and obliterative in 26 patients (7%). One hundred thirty-seven patients underwent partial stapedectomy (35.6%), 232 patients stapedotomy (60.4%) and 15 patients (4%) “unplanned” total stapedectomy, which was usually performed in case of footplate dislocation during surgical manoeuvres. A 0.6 mm piston was used in 221 patients (57.4%) and a 0.4 mm piston in the remaining 163 patients (42.6%). In Table I patients are classified according to the technique and prosthesis diameter.

No patients developed major complications such as dead ear or permanent facial palsy; minor complications such as temporary vertigo, tinnitus and facial palsy occurred in 60 patients (15.6%): namely 40 patients developed transient vertigo (10.4%), 18 transient tinnitus (4.6%) and 2 transient facial palsy (0.5%). All patients recovered within 15 days after surgery.

Overall mean pre-operative air conduction pure tone average (PTA) was 62.21 dB (range: 32-106; SD: ± 14 dB), whereas overall mean post-operative air conduction PTA was 36.45 dB (range: 11-70; SD: ± 12 dB). Overall mean pre-operative ABG was 33.8 dB (range: 20-61; SD: ± 9 dB), whereas overall mean post-operative ABG was 9.5 dB (range: 0-31; SD: ± 6 dB). Differences between pre- and post-operative overall PTA and ABG were statistically significant (p = 0.003 and p = 0.002 respectively). Mean post-operative ABG gain was 24.3 dB (range: 0-50; SD: ± 11 dB). ABG worsening was never reported. Overall mean pre-operative bone conduction PTA (BCPTA) was 28 dB (range: 10-66 dB; SD ± 11 dB), whereas overall mean post-operative BCPTA was 27 dB (range: 9-62; SD: ± 10 dB). The difference between overall pre- and post-operative mean BCPTA was not statistically significant (p = 0.23). Mean pre- and post-operative audiological data, stratified according to otosclerosis pattern, surgical procedure and prosthesis diameter are reported in Table II.

Otosclerosis pattern

Statistical analysis did not show significant differences between mean post-operative ABG in peripheral rim versus diffuse otosclerosis (mean post-operative ABG = 8.6 dB vs 9.9 dB respectively; p = 0.09). Mean post-operative ABG was significantly higher in obliterative otosclerosis (mean post-operative ABG = 14.07 dB in the latter group, p = 0.0003) (Fig. 1). Moreover, in peripheral rim and diffuse otosclerosis mean post-operative BCPTA increased by 2.2 and 2.1 dB, respectively, whereas it decreased by 1.2 dB in obliterative otosclerosis. The difference was not significant (p = 0.06). No statistically significant differences were noted in the prevalence of the surgical technique performed, while a 0.4 mm prosthesis was used in a significantly higher number of obliterative otosclerosis compared to the other techniques (p = 0.01) (Table III).

Surgical technique

No significant differences were detected in terms of mean post-operative ABG according to the type of surgical technique (Fig. 2). In detail, only post-operative ABG at 0.5 kHz was significantly higher in the stapedotomy group compared to the partial stapedectomy group and the total stapedectomy group (respectively mean post-operative ABG = 11.2 dB vs 8.6 dB and 8 dB; p = 0.003). No significant differences were encountered in terms of mean post-operative BCPTA change according to the type of surgical technique.

Piston diameter

No significant differences were found according to the piston diameter in the overall population. Mean post-operative ABG was significantly higher in the 0.4 mm, compared to 0.6 mm piston group at 0.5 kHz (14 dB vs 7.5 dB respectively; p = 0.0001) and 1 kHz only (11.2 dB vs 9.0 dB respectively; p = 0.015), whereas no significant differences were found at the other frequencies (p = 0.1) (Fig. 3).

Moreover, in the partial stapedectomy group the mean post-operative ABG did not significantly differ between the 0.4 and 0.6 mm piston groups (9.1 dB in both), while in the stapedotomy group a significant difference was found between 0.4 and 0.6 mm piston groups in favour of the latter (respectively 10.6 vs 7.83 dB; p = 0.04).

Analysis of mean BCPTA change demonstrated the absence of a significant difference between the 0.4 mm and 0.6 mm-diameter groups (p = 0.09).

Post-operative complications

Details regarding the association between complications and surgical variables are reported in Table IV. Temporary complications (namely tinnitus, vertigo and facial palsy) were significantly higher in case of obliterative otosclerosis, 0.6 mm piston and in patients subjected to total stapedectomy (p = 0.035).


The population of the present study achieved satisfactory functional results, with a mean post-operative ABG of 9.5 dB and a post-operative ABG lower than 20 dB in 93% of cases, in agreement with our previous reports 12 21. Moreover, mean BCPTA improved by 1.7 dB and permanent complications were never reported.

Otosclerosis pattern

We adopted a classification based on the Portmann and Malafronte system, to synthesise both anatomical diffusion and histologic appearance. Well delimited rim and diffuse otosclerosis were associated with better hearing results compared to obliterative otosclerosis. “Blue” and “White” patterns, similar to the report by Malafronte et al., do not differ significantly on post-operative hearing function, since significant differences are reported in comparison to the “obliterative” pattern outcome only. An experienced surgeon, in fact, should be able to quickly differentiate, before removal of the superstructure, the intrinsic risk of intra-operative manipulation, according to the macroscopic appearance 22. Although diffuse otosclerosis is considered as more challenging, specific competence allows to obtain comparable results in diffuse versus limited otosclerotic focus. On the other hand, the greater surgical difficulty of obliterative otosclerosis has been fully described in the literature. Daniels 23 demonstrated in a large cohort, the higher complexity in the drill-out of the oval window in the obliterative pattern, leading to a significantly lower rate of ABG closure and higher rate of sensorineural hearing loss when compared to a routine stapedectomy. Also, in our results mean post-operative ABG was significantly higher in obliterative otosclerosis, compared to other patterns, although mean post-operative HFBC only showed a slight decrease, which did not reach statistical significance. Moreover, no difference was found in the choice of the surgical technique in the obliterative pattern vs. the others. We found, however, that in the majority of obliterative cases a 0.4 mm-diameter prosthesis was positioned, with a significantly higher prevalence compared to the other patterns. This might be easily explained by the difficulty encountered in the extensive drill-out of a thick and friable footplate and represents a bias in the assessment of functional results obtained through different prosthesis diameters.

No patients affected by obliterative otosclerosis experienced a permanent complication. However, a significantly higher incidence of temporary complications (30.7%) was recorded compared to the other patterns. The most frequent symptom was dizziness, reported by 7/26 patients (26.9%). These results indicate that extensive drilling might cause a temporary dysfunction of sensory hair cells, leading to transient vertigo and/or tinnitus in a significantly higher percentage of patients. However, this does not translate into permanent inner ear damage, since HFBC remained stable.

Surgical technique

No functional differences were seen among the three surgical groups, since no statistically significant differences were found in mean post-operative ABG and HFBC. The significant difference in ABG at 0.5 kHz, in favour of the stapedectomy group, is consistent with reports advocating a slightly better performance obtained in the lower frequencies 13-15 due to the wider surface of the oval window that is removed. Mean post-operative HFBC change does not differ significantly, according to the surgical technique. Hair cell damage caused by the surgical trauma was similar among the three groups and the greater or smaller surface of restored footplate does not influence post-operative bone conduction 15 24.

Several studies were conducted regarding comparison of functional outcomes in stapedotomy versus stapedectomy, with controversial results 12-15. Stapedotomies have been reported in the literature to have better hearing improvements at high frequencies 12. In other studies, stapedectomies have been advocated for higher hearing improvement at low frequencies 13-15. In our previous study on 151 subjects 12, we reported that stapedotomy and partial stapedectomy have equivalent results in term of ABG closure and air conduction gain in the speech frequencies. However, stapedotomy was associated with better ABG closure at 4 kHz, ABG gain at 2, 3, and 4 kHz and greater air conduction gain in the high frequencies (4 to 8 kHz). Sakamoto et al. 25 demonstrated, in a 99 ear cohort, that stapedotomies were more effective on global hearing function compared to stapedectomies. Rizer 26 on the contrary demonstrated better results at 0.5-3 kHz with partial or total stapedectomy compared to stapedotomy. Several authors have shown overlapping hearing outcomes between stapedotomy and partial stapedectomy 24.

The controversial results obtained in the literature in terms of the “optimal” technique may be influenced by multiple factors such as instruments used to remove the footplate (microhook, perforator, microdrill, lasers), diameter and material of the pistons, vein or connective tissue interposition and experience of the surgeon. Moreover, intrinsic bias cannot be avoided since a significant portion of stapedotomies are converted into stapedectomy during the operation and several surgeons prefer to perform stapedotomy selectively in patients with favourable anatomic conditions, whereas stapedectomy is reserved for complicated cases.

The results of the present series show that, among morphological variables, the macroscopic otosclerosis pattern did not influence our choice. In fact, no significant difference exists in the prevalence of various patterns among the three surgical groups (see Table III). In case of total stapedectomy we used a 0.6 mm diameter prosthesis in all cases, expecting a larger prosthesis, together with a graft composed of earlobe fat and blood, to have more stability in an entirely open oval window. A tendency towards using larger diameter prosthesis is shown even in the partial stapedectomy group, compared to the stapedotomy group (Table I).

Finally, a significant increase of the risk of complications was recorded in the total stapedectomy group (33.3% of cases) 25. Both transient vertigo and tinnitus, due to vestibular trauma deriving from the manipulation and total removal of the footplate were reported.

Piston diameter

We systematically used a Teflon-piston prosthesis in our patients, according to the study by Durko 27, who considered this material as the best option. A recent review on 12 studies 16 showed that the majority of those could not show a significant difference between 0.4 and 0.6 pistons. Moreover, differences that were detected were not consistently in favour of a smaller or larger-diameter piston. On the contrary, a meta-analysis by Laske et al. 11 reported that a 0.6-mm piston is associated with significantly better post-operative ABG at low and mid frequencies, compared to a 0.4 mm prosthesis. Bernardeschi et al. 28 demonstrated a significant difference in AC gain, AC threshold at 0.125 and 0.25 kHz and BC threshold at 0.25 kHz in favour of the 0.6-mm group. The latter study is one of the few to be designed as a prospective one, on consecutive cohorts, with minimum risk of bias.

According to our analysis, no significant difference was seen in mean post-operative ABG and HFBC in 0.4 mm versus 0.6 mm piston diameter, although the latter provides better ABG values at low frequencies. Although unanimous consensus has not been reached, it is reasonable to assume that an extremely narrow piston does not effectively transmit sound energy into the vestibule, producing less volume displacement especially at lower frequencies. On the contrary, a larger prosthesis has a larger surface area of transmission. The increased portion of the cochlea stimulated by the prosthesis diameter-to-footplate ratio could explain the better results of pistons with a higher diameter. Experimental studies on temporal bones have demonstrated increased round window velocities and higher perilymphatic volume displacement 29 30 with larger diameter prosthesis. We believe that when anatomical conditions allow a choice, a larger-diameter piston may be preferable.

Our study has some limitations due to the retrospective and non-randomised nature, heterogeneous follow-up duration and intrinsic methodological bias. Several critical procedures were in fact accidentally converted in total stapedectomies, the choice of technique and prosthesis diameter was influenced by anatomic conditions, hearing condition or size of the fenestration. Smaller-diameter pistons are usually preferred in case of unfavourable anatomic conditions (dehiscent/overhanging facial nerve, narrow oval window niche, persistent stapedial artery), affecting the association with hearing outcome. Moreover, functional outcome is influenced by other factors, besides those mentioned above, such as pre-operative threshold, cochlear function, anatomical conditions, experience of the surgeon and efficacy of prosthesis crimping.


A well-delimited rim and diffuse otosclerosis patterns and 0.6 mm-diameter piston can be considered as factors associated with better outcome. No functional differences were detected when comparing partial stapedectomy, total stapedectomy and stapedotomy. Obliterative otosclerosis represents an unfavourable prognostic factor, although significant sensorineural hearing loss or permanent complications were not recorded. It is not possible, at the state of our knowledge, to pre-operatively predict the extent of the otosclerotic focus, although radiologic and audiometric indicators have been proposed 31 32. In our opinion, the only factor considered as adequate and the less hazardous in possible intra-operative management is the experience of the surgeon.

Figures and tables

Fig. 1.Comparison of mean post-operative ABG among different otosclerosis patterns (peripheral rim, diffuse and obliterative).

Fig. 2.Mean post-operative ABG according to surgical technique and piston diameter.

Fig. 3.Comparison of post-operative ABG between 0.4 mm and 0.6 mm-diameter piston at 0.5, 1, 2 and 4 kHz.

0.6 mm piston 0.4 mm piston Total
Partial stapedectomy 100 (72.9%) 37(27%) 137
Stapedotomy 106 (45.6%) 126 (54.4%) 232
Total stapedectomy 15 (100%) 0 (0%) 15
Total 221 163 384
Table I.Patient stratification according to surgical technique and prosthesis diameter.
Surgical technique Prosthesis diameter Otosclerosis pattern
Partial stapedectomy Stapedotomy Total stapedectomy 0.4 mm 0.6 mm Peripheral rim Diffuse Obliterative
Mean post-operative PTA (dB) 36.4 (n.s.) 36.7 (n.s.) 34 (n.s.) 38.5 (n.s.) 34.8 (n.s.) 37 (n.s.) 35.5 (n.s.) 40.9 (p < 0.001)
Mean post-operative ABG (dB) 9.1 (n.s.) 9.6 (n.s.) 11.2 (n.s.) 10.3 (n.s.) 8.9 (n.s.) 9.9 (n.s.) 8.6 (n.s.) 14 (p < 0.001)
ABG Gain (dB) 23.4 (n.s.) 25 (n.s.) 19.8 (n.s.) 23.8 (n.s.) 24.7 (n.s.) 22.2 (n.s.) 25.1 (n.s.) 25.1 (n.s.)
Post-operative mean BCPTA (dB) 27.3 (n.s.) 27 (n.s.) 22.5 (n.s.) 28.2 (n.s.) 25.9 (n.s.) 27.1 (n.s.) 26.8 (n.s.) 26.9 (n.s.)
HFBC Change (dB) 1.6 (n.s.) 2 (n.s.) 0 (n.s.) 1.5 (n.s.) 1.9 (n.s.) 2.2 (n.s.) 2.1 (n.s.) 0 (n.s.)
Table II.Multilinear regression analysis showing mean pre- and post-operative audiological data, stratified according to surgical procedure, prosthesis diameter and otosclerosis pattern.
Surgical technique Prosthesis diameter
Partial stapedectomy Stapedotomy Total stapedectomy 0.4 mm 0.6 mm
Peripheral rim (n = 186) 66 (35.4%) (n.s.) 112 (60.3%) (n.s.) 8 (4.3%) (n.s.) 73 (39.2%) (n.s.) 113 (60.8%) (n.s.)
Diffuse (n = 172) 65 (37.8%) (n.s.) 102 (59.3%) (n.s.) 5 (2.9%) (n.s.) 69 (40.1%) (n.s.) 103 (59.9%) (n.s.)
Obliterative (n = 26) 6 (23%) (n.s.) 18 (69.2%) (n.s.) 2 (7.8%) (n.s.) 21 (80.7%) (p < 0.05) 5 (19.3%) (p < 0.05)
Table III.Stratification of surgical procedure and diameter of the prosthesis according to the otosclerotic pattern.
Overall(n = 60) Temporary vertigo(n = 40) Tinnitus(n = 18) Facial palsy(n = 2)
Surgical technique Partial stapedectomy 26/137 (18.9%)(p < 0.05) 18/137 (13.1%) (n.s.) 7/137 (5.1%)(p < 0.05) 1/137 (0.7%)(n.s.)
Stapedotomy 29/232 (12.5%)(p < 0.05) 19/232 (8.1%) (n.s.) 9/232 (3.8%)(p < 0.05) 1/137 (0.7%)(n.s.)
Total stapedectomy 5/15 (33.3%)(p < 0.05) 3/15 (20%) (n.s.) 2/15 (13.3%)(p < 0.05) 0/15 (0%)(n.s.)
Prosthesis diameter 0.4 mm 15/163 (9.2%)(p < 0.05) 11/163 (6.7%) (n.s.) 3/163 (1.8%)(n.s.) 1/163 (0.6%)(n.s.)
0.6 mm 45/221 (20.3%)(p < 0.05) 29/221 (13.1%) (n.s.) 15/221 (6.8%)(n.s.) 1/221 (0.4%)(n.s.)
Otosclerosis pattern Peripheral rim 26/186 (13.9%)(p < 0.05) 13/186 (6.9%)(p < 0.05) 12/186 (6.4%)(n.s.) 1/186 (0.5%)(n.s.)
Diffuse 26/172 (15.1%)(p < 0.05) 20/172 (11.6%)(p < 0.05) 5/172 (2.9%)(n.s.) 0/26 (0%)(n.s.)
Obliterative 8/26 (30.7%)(p < 0.05) 7/26 (26.9%)(p < 0.05) 1/26 (3.8%)(n.s.) 0/26 (0%)(n.s.)
Table IV.Incidence of temporary complications stratified according to the intra-operative parameters.


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UOC Otorinolaringoiatria Universitaria, Azienda Ospedaliero-Universitaria Policlinico di Bari, Italy


UOC Otorinolaringoiatria Universitaria, Azienda Ospedaliero-Universitaria Policlinico di Bari, Italy


UOC Otorinolaringoiatria, Fondazione Policlinico A. Gemelli-IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy


UOC Otorinolaringoiatria, Fondazione Policlinico A. Gemelli-IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy


UOC Otorinolaringoiatria, Fondazione Policlinico A. Gemelli-IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy


© Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale , 2019

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